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中华腔镜泌尿外科杂志(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 86 -89. doi: 10.3877/cma.j.issn.1674-3253.2018.02.005

所属专题: 文献

临床研究

生长相关蛋白-43在间质性膀胱炎患者膀胱黏膜表达的研究
杨飞1, 蔡佳荣1, 李腾成1, 刘柏隆1, 湛海伦1, 周祥福1,()   
  1. 1. 510530 广州,中山大学附属第三医院岭南医院泌尿外科
  • 收稿日期:2017-08-03 出版日期:2018-04-01
  • 通信作者: 周祥福
  • 基金资助:
    广东省自然科学基金(2016A030313192,2017A030310414); 广东省医学科学技术研究基金项目(A2017365); 国家自然科学基金(81670688)

The expression of growth associated protein 43 in bladder tissue of patients with interstitial cystitis

Fei Yang1, Jiarong Cai1, Tengcheng Li1, Bolong Liu1, Hailun Zhan1, Xiangfu Zhou1,()   

  1. 1. Department of Urology, Linnan Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510530, China
  • Received:2017-08-03 Published:2018-04-01
  • Corresponding author: Xiangfu Zhou
  • About author:
    Corresponding author: Zhou Xiangfu, Email:
引用本文:

杨飞, 蔡佳荣, 李腾成, 刘柏隆, 湛海伦, 周祥福. 生长相关蛋白-43在间质性膀胱炎患者膀胱黏膜表达的研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2018, 12(02): 86-89.

Fei Yang, Jiarong Cai, Tengcheng Li, Bolong Liu, Hailun Zhan, Xiangfu Zhou. The expression of growth associated protein 43 in bladder tissue of patients with interstitial cystitis[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2018, 12(02): 86-89.

目的

探讨生长相关蛋白43(GAP-43)在间质性膀胱炎/膀胱疼痛综合征(IC/BPS)患者膀胱黏膜组织中的表达情况,以及与患者症状严重程度之间的相关性。

方法

通过免疫组织化学法检测GAP-43在31例IC/BPS患者膀胱组织中的表达情况,并通过入院时对全部病例进行症状评分(ICSI),问题评分(ICPI)和盆腔疼痛、尿频/尿急症状评分(PUF),评估GAP-43的表达与IC/BPS患者症状严重性之间的相关性。

结果

31例IC/BPS患者中,ICSI 13~19分,平均(16±3)分;ICPI 7~16分,平均(12±1)分。PUF 16~25分,平均(20±2)分。症状总分37~57分,平均(46±4)分。IC/BPS患者膀胱组织中GAP-43表达水平免疫组化评分为0~6分,平均(5.2±0.3)分。GAP-43在IC/BPS患者膀胱组织中的表达程度与患者的症状严重程度(ICSI+ICPI、PUF、ICSI+ICPI+PUF)之间成正相关(相关系数=0.469、0.611、0.426),具有统计学意义(P=0.046、0.039、0.008)。

结论

GAP-43在IC/BPS患者膀胱组织中的表达与患者的症状严重程度成正相关,提示GAP-43在IC/BPS的发病机制中可能起着一定的作用。

Objective

To explore the growth associated protein (GAP-43) expression in patients with interstitial cystitis/bladder painful syndrome (IC/BPS) and the correlation between symptoms.

Methods

Through the immune histochemical method to detect GAP-43 expression in bladder tissue of 31 patients with IC/BPS, ICSI, ICPI and PUF score before treatment, and the ralationship between GAP-43 expression and patient's symptoms were assessed.

Results

Of 31 IC/BPS patients, ICSI scores were ranged from 13 to 19 (mean 16±3), ICPI scores were ranged from 7 to 16 (mean 12±1), PUF scores were ranged from 16 to 25 (mean 20±2), symptom scores were ranged from 37 to 57 (46±4). The expression of GAP-43 immune histochemical scores were ranged from 1 to 6 (mean 5.2 ± 0.3) points. There was a positive correlation between GAP-43 expression levels in the bladder tissue and symptom severity of IC/BPS patients, correlation coefficients were 0.469, 0.611, 0.426 respectively, P value were 0.046, 0.039, 0.008 respectively.

Conclusion

GAP-43 expression in bladder tissue of IC/BPS patients are positively related to the patient's symptom severity, suggesting that GAP-43 expression in bladder tissue may be involved in the pathogenesis of IC/BPS.

图1 IC/BPS患者膀胱上皮下固有膜内GAP-43染色阳性神经纤维(×200)
图4 GAP-43与症状总分呈正相关(RR=0.426,P=0.039)
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