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中华腔镜泌尿外科杂志(电子版) ›› 2022, Vol. 16 ›› Issue (06) : 555 -558. doi: 10.3877/cma.j.issn.1674-3253.2022.06.014

病例研究

膀胱副神经节瘤二例报告及文献复习
吴曦1, 宋文1, 高风雷1, 董文奎1, 黄恒2, 黄兴3,()   
  1. 1. 441800 湖北省老河口市第一医院泌尿外科
    2. 441800 湖北省老河口市第一医院病理科
    3. 430071 武汉大学中南医院泌尿外科
  • 收稿日期:2021-09-24 出版日期:2022-12-01
  • 通信作者: 黄兴

Paraganglioma of urinary bladder: a report of 2 cases and literature review

Xi Wu1, Wen Song1, Fenglei Gao1, Wenkui Dong1, Heng Huang2, Xing Huang3,()   

  1. 1. Department of Urology, the First People’s Hospital of Laohekou, Hubei 441800, China
    2. Department of Pathology, the First People’s Hospital of Laohekou, Hubei 441800, China
    3. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  • Received:2021-09-24 Published:2022-12-01
  • Corresponding author: Xing Huang
引用本文:

吴曦, 宋文, 高风雷, 董文奎, 黄恒, 黄兴. 膀胱副神经节瘤二例报告及文献复习[J]. 中华腔镜泌尿外科杂志(电子版), 2022, 16(06): 555-558.

Xi Wu, Wen Song, Fenglei Gao, Wenkui Dong, Heng Huang, Xing Huang. Paraganglioma of urinary bladder: a report of 2 cases and literature review[J]. Chinese Journal of Endourology(Electronic Edition), 2022, 16(06): 555-558.

目的

探讨膀胱副神经节瘤的临床病理特征及其诊治方法。

方法

回顾性分析2例膀胱副神经节瘤患者的临床资料,分析该病的临床病理特征、诊断及治疗方法,并对相关文献进行回顾和总结。

结果

病例1为无功能性肿瘤,体检发现膀胱占位,CT增强扫描明显强化,肿瘤为单发,行经尿道膀胱肿瘤电切术。病例2为功能性肿瘤,主要临床表现为头痛、心悸、排尿后血压一过性升高,MRI增强结节不均匀强化,肿瘤为单发,术前降压扩容后行腹腔镜膀胱部分切除术,术后症状消失。术后病理诊断均为膀胱副神经节瘤。随访9~12个月,均无复发或转移。

结论

膀胱副神经节瘤临床罕见,可分为功能性和非功能性,术前需充分检查及准备,术中预防血压波动引起的高血压危象,经尿道膀胱肿瘤电切术及腹腔镜膀胱部分切除术均效果良好,术后需密切随访。

Objective

To explore the clinicopathological features, diagnosis and treatment of paraganglioma of urinary bladder (PUB).

Methods

The clinical data, pathological diagnosis and follow-up results of 2 cases with paraganglioma of urinary bladder in our hospital were analyzed retrospectively, and related literatures were also reviewed.

Results

Case 1 was nonfunctional neoplasm without any symptoms. CT scan showed a solitary bladder nodule and was significantly enhanced. The patient underwent transurethral resection of the bladder tumor (TURBT). Case 2 was functional neoplasm with symptoms of headache, palpitation, and paroxysmal hypertension after urination, MRI showed a solitary bladder nodule with heterogeneous enhancement. After sufficient preparation including volume expansion and stability of blood pressure, the patient underwent laparoscopic partial cystectomy and the symptoms disappeared after surgery. There was no tumor recurrence or metastasis through the 9 to 12 months follow-up.

Conclusions

PUB is a rare tumor in clinical and can be classified as functional or nonfunctional tumors. Fully preparations should be made to prevent complications such as hypertensive crisis during operation. TURBT and laparoscopic partial cystectomy are effective treatment methods and regular follow-up after surgery is necessary.

图2 膀胱副神经节瘤病例2影像及病理资料
[1]
Pastor-Guzmán JM, López-García S, Giménez-Bachs JM, et al. Paraganglioma of the bladder: controversy regarding treatment[J]. Urol Int, 2004, 73(3): 270-275.
[2]
Zimmerman IJ, Biron RE, Macmahon HE. Pheochromocytoma of the urinary bladder[J]. N Engl J Med, 1953, 249(1): 25-26.
[3]
Beilan JA, Lawton A, Hajdenberg J, et al. Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature[J]. BMC Urol, 2013, 13: 22.
[4]
Zhai HY, Ma X, Nie WY, et al. Paraganglioma of the urinary bladder: a series of 22 cases in a single center[J]. Clin Genitourin Cancer,2017, 15(5): e765-e771.
[5]
Naqiyah I, Rohaizak M, Meah FA, et al. Phaeochromocytoma of the urinary bladder[J]. Singapore Med J, 2005, 46(7): 344-346.
[6]
石都, 孔垂泽, 李振华. 膀胱副神经节瘤的诊断与治疗(附10例报道)[J]. 中国医科大学学报, 2019, 48(10): 944-947.
[7]
谌丹丹, 魏新华, 杨蕊梦, 等. 膀胱神经内分泌肿瘤的CT表现[J]. 临床放射学杂志, 2020, 39(4): 736-740.
[8]
Liang JP, Li HG, Gao LK, et al. Bladder paraganglioma: clinicopathology and magnetic resonance imaging study of five patients[J]. Urol J, 2016, 13(2): 2605-2611.
[9]
Pahwa HS, Kumar A, Srivastava R, et al. Urinary bladder paraganglioma-a case series with proposed treating algorithm based on our experience and review of literature[J]. Indian J Surg Oncol, 2013, 4(3): 294-297.
[10]
Mithqal A, Darvishi P, Rehm P. MIBG localization of a subclinical paraganglioma of the bladder[J]. Clin Nucl Med, 2017, 42(4): e196-e198.
[11]
Iwamoto G, Kawahara T, Tanabe M, et al. Paraganglioma in the bladder: a case report[J]. J Med Case Rep, 2017, 11(1): 306.
[12]
侯国良, 徐文峰, 刘建华, 等. 膀胱副神经节瘤6例临床病理分析[J/CD]. 中华腔镜泌尿外科杂志(电子版), 2019, 13(4): 234-237.
[13]
Ko A, Ezzeldin O, Bezold S, et al. Metastatic urinary bladder paraganglioma on Ga-68 DOTATATE PET/CT[J]. Radiol Case Rep, 2021, 16(9): 2763-2767.
[14]
Yin DH, Jiao WP, Li XL, et al. Paraganglioma of the urinary bladder: a case report[J]. Asian J Surg, 2021, 44(7): 1002-1003.
[15]
张瑞敏, 张建国, 赵永祥. 双极电刀经尿道切除膀胱副神经节瘤一例[J/CD]. 中华腔镜泌尿外科杂志(电子版), 2017, 11(2): 139-140.
[16]
Tu X, Zhang N, Zhuang X, et al. Incidental diagnosis of nonfunctional bladder paraganglioma: a case report and literature review[J]. BMC Urol, 2021, 21(1): 98.
[17]
Lu HY, Male M, Jiang KH, et al. Clinical significance of functional and anatomical classifications in paraganglioma of the urinary bladder[J]. Urol Oncol, 2019, 37(6): 354.e9-354.e17.
[18]
柯春锦, 田继华, 杨春光, 等. 膀胱副神经节瘤的诊治(附3例报告)[J]. 现代泌尿生殖肿瘤杂志, 2019, 11(5): 274-277.
[19]
刘鑫, 张劲松, 王海峰, 等. 膀胱副神经节瘤5例报告及文献复习[J]. 临床泌尿外科杂志, 2019, 34(12): 980-983.
[20]
Stigliano A, Lardo P, Cerquetti L, et al. Treatment responses to antiangiogenetic therapy and chemotherapy in nonsecreting paraganglioma (PGL4) of urinary bladder with SDHB mutation: a case report[J]. Medicine, 2018, 97(30): e10904.
[21]
Cheng L, Kouba E. Neuroendocrine tumors of the urinary bladder according to the 2016 world health organization classification: molecular and clinical characteristics[J]. Endocr Pathol, 2016, 27(3): 188-199.
[22]
Safwat AS, Bissada NK. Pheochromocytoma of the urinary bladder[J]. Can J Urol, 2007, 14(6): 3757-3760.
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