切换至 "中华医学电子期刊资源库"

中华腔镜泌尿外科杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 514 -520. doi: 10.3877/cma.j.issn.1674-3253.2025.04.019

所属专题: 文献

综述

预康复在泌尿系统恶性肿瘤患者中的研究进展
李菊, 王留芳(), 叶春伟, 刘玉芹, 和志梅   
  1. 650033 云南,昆明医科大学第二附属医院泌尿外科
  • 收稿日期:2024-08-26 出版日期:2025-08-01
  • 通信作者: 王留芳
  • 基金资助:
    国家自然科学地区基金(82060533)

Research progress of prehabilitation in patients with urological malignancies

Ju Li, Liufang Wang(), Chunwei Ye, Yuqin Liu, Zhimei He   

  1. Department of Urology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650033, China
  • Received:2024-08-26 Published:2025-08-01
  • Corresponding author: Liufang Wang
引用本文:

李菊, 王留芳, 叶春伟, 刘玉芹, 和志梅. 预康复在泌尿系统恶性肿瘤患者中的研究进展[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(04): 514-520.

Ju Li, Liufang Wang, Chunwei Ye, Yuqin Liu, Zhimei He. Research progress of prehabilitation in patients with urological malignancies[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2025, 19(04): 514-520.

泌尿系统恶性肿瘤患者常因自身生理与心理因素,导致术前心肺功能及肌肉功能储备不足,这种储备不足会削弱其对手术应激反应的适应能力,进而影响术后康复进程。预康复作为加速康复外科(ERAS)的有益补充,强调以术前阶段为干预时机,通过采取单一或多元的干预措施,优化患者术前器官功能,提高手术创伤的耐受和适应水平,改变术后结局。本文对泌尿系统恶性肿瘤患者术前预康复实施的必要性、实施内容以及实施效果进行综述,为预康复在我国临床的进一步推广提供参考。

Patients with malignant tumors of the urinary system often exhibit insufficient preoperative cardiopulmonary function and muscle reserve due to their own physiological and psychological factors. This diminished reserve capacity weakens their adaptive response to surgical stress, thereby consequently affecting the postoperative recovery process. As a beneficial supplement of enhanced recovery after surgery(ERAS), prehabilitation emphasizes taking the preoperative stage as the intervention opportunity, and adopts single or multiple intervention measures to optimize the preoperative organ function of patients, improve the tolerance and adaptation of surgical trauma, and change the postoperative outcome. This article reviewed the necessity, contents and effects of prehabilitation in patients with urological malignancies, and provided reference for further promotion of prehabilitation in China.

[1]
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263. DOI: 10.3322/caac.21834.
[2]
Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022[J]. J Natl Cancer Cent, 2024, 4(1): 47-53. DOI: 10.1016/j.jncc.2024.01.006.
[3]
吴柔娜, 晁敏, 毛琳. 加速康复外科在我国的研究现状及展望[J]. 加速康复外科杂志, 2022, 5(3): 123-129.
[4]
李幼生. 从加速康复外科到预康复——理念更新与临床实践模式转变[J]. 中国实用外科杂志, 2024, 44(2): 155-159. DOI: 10.19538/j.cjps.issn1005-2208.2024.02.08.
[5]
Gabriel KP, Jaeger BC, Lewis CE, et al. Analysis of cardiorespiratory fitness in early adulthood and midlife with all-cause mortality and fatal or nonfatal cardiovascular disease[J]. JAMA Netw Open, 2023, 6(2): e230842. DOI: 10.1001/jamanetworkopen.2023.0842.
[6]
Gillis C, Ljungqvist O, Carli F. Prehabilitation, enhanced recovery after surgery, or both?A narrative review[J]. Br J Anaesth, 2022, 128(3): 434-448. DOI: 10.1016/j.bja.2021.12.007.
[7]
王欣, 刘菲, 李晓凤, 等. 基于Web of Science数据库的预康复研究态势及热点分析[J]. 护士进修杂志, 2021, 36(17): 1537-1545, 1564. DOI: 10.16821/j.cnki.hsjx.2021.17.001.
[8]
刘言, 朱蓝玉, 李佳, 等. 预康复在癌症外科手术领域应用的可视化分析[J]. 循证护理, 2024, 10(10): 1795-1802. DOI: 10.12102/j.issn.2095-8668.2024.10.014.
[9]
汪夏云, 朱晓萍, 吴茜. 77所三级综合医院加速康复外科开展现状及障碍因素分析[J]. 四川大学学报(医学版), 2023, 54(5): 1000-1005.
[10]
Dobson GP. Trauma of major surgery: a global problem that is not going away[J]. Int J Surg, 2020, 81: 47-54. DOI: 10.1016/j.ijsu.2020.07.017.
[11]
Rose GA, Davies RG, Appadurai IR, et al. 'Fit for surgery': the relationship between cardiorespiratory fitness and postoperative outcomes[J]. Exp Physiol, 2022, 107(8): 787-799. DOI: 10.1113/EP090156.
[12]
商思懿, 刘桐桐, 陈圣光, 等. 老年人躯体复原力的研究进展[J]. 军事护理, 2023, 40(10): 88-91, 95. DOI: 10.3969/j.issn.2097-1826.2023.10.021.
[13]
Skořepa P, Ford KL, Alsuwaylihi A, et al. The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: a systematic review and meta-analysis[J]. Clin Nutr, 2024, 43(3): 629-648. DOI: 10.1016/j.clnu.2024.01.020.
[14]
Yuan S, Larsson SC. Epidemiology of sarcopenia: prevalence, risk factors, and consequences[J]. Metabolism, 2023, 144: 155533. DOI: 10.1016/j.metabol.2023.155533.
[15]
Brunckhorst O, Hashemi S, Martin A, et al. Depression, anxiety, and suicidality in patients with prostate cancer: a systematic review and meta-analysis of observational studies[J]. Prostate Cancer Prostatic Dis, 2021, 24(2): 281-289. DOI: 10.1038/s41391-020-00286-0.
[16]
Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis[J]. Age Ageing, 2019, 48(1): 16-31. DOI: 10.1093/ageing/afy169.
[17]
Witjes JA, Bruins HM, Cathomas R, et al. European association of urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines[J]. Eur Urol, 2021, 79(1): 82-104. DOI: 10.1016/j.eururo.2020.03.055.
[18]
Mayr R, Fritsche HM, Zeman F, et al. Sarcopenia predicts 90-day mortality and postoperative complications after radical cystectomy for bladder cancer[J]. World J Urol, 2018, 36(8): 1201-1207. DOI: 10.1007/s00345-018-2259-x.
[19]
Robertson HL, Michel C, Bartl L, et al. Sarcopenia in urologic oncology: Identification and strategies to improve patient outcomes[J]. Urol Oncol, 2022, 40(11): 474-480. DOI: 10.1016/j.urolonc.2020.05.001.
[20]
Weimann A, Braga M, Carli F, et al. ESPEN practical guideline: Clinical nutrition in surgery[J]. Clin Nutr, 2021, 40(7): 4745-4761. DOI: 10.1016/j.clnu.2021.03.031.
[21]
Dent E, Martin FC, Bergman H, et al. Management of frailty: opportunities, challenges, and future directions[J]. Lancet, 2019, 394(10206): 1376-1386. DOI: 10.1016/S0140-6736(19)31785-4.
[22]
Shaw JF, Budiansky D, Sharif F, et al. The association of frailty with outcomes after cancer surgery: a systematic review and metaanalysis[J]. Ann Surg Oncol, 2022, 29(8): 4690-4704. DOI: 10.1245/s10434-021-11321-2.
[23]
Taylor BL, Xia L, Guzzo TJ, et al. Frailty and greater health care resource utilization following major urologic oncology surgery[J]. Eur Urol Oncol, 2019, 2(1): 21-27. DOI: 10.1016/j.euo.2018.06.005.
[24]
李佳欣, 刘子薇, 尚娅萌, 等. 癌症患者久坐行为的研究进展[J]. 护理学报, 2022, 29(23): 22-27. DOI: 10.16460/j.issn1008-9969.2022.23.022.
[25]
Levett DH, Grimmett C. Psychological factors, prehabilitation and surgical outcomes: evidence and future directions[J]. Anaesthesia, 2019, 74(Suppl 1): 36-42. DOI: 10.1111/anae.14507.
[26]
刘子嘉, 黄宇光. "三联预康复": ERAS的术前优化[J]. 医学与哲学(B), 2017, 38(6): 12-14. DOI: 10.12014/j.issn.1002-0772.2017.06b.03.
[27]
Mungovan SF, Carlsson SV, Gass GC, et al. Preoperative exercise interventions to optimize continence outcomes following radical prostatectomy[J]. Nat Rev Urol, 2021, 18(5): 259-281. DOI: 10.1038/s41585-021-00445-5.
[28]
Dal Bello S, Mancin S, Morales Palomares S, et al. Nutritional prehabilitation in patients undergoing cystectomy: a systematic review[J]. Nutrients, 2024, 16(11): 1682. DOI: 10.3390/nu16111682.
[29]
Coderre D, Brahmbhatt P, Hunter TL, et al. Cancer prehabilitation in practice: the current evidence[J]. Curr Oncol Rep, 2022, 24(11): 1569-1577. DOI: 10.1007/s11912-022-01304-1.
[30]
Briggs LG, Reitblat C, Bain PA, et al. Prehabilitation exercise before urologic cancer surgery: a systematic and interdisciplinary review[J]. Eur Urol, 2022, 81(2): 157-167. DOI: 10.1016/j.eururo.2021.05.015.
[31]
Hunter H, Bennington-McKay N, Sher J, et al. Emerging role of mobile applications and wearable devices for prehabilitation in urologic oncology[J]. Eur Urol Focus, 2024, 10(1): 20-22. DOI: 10.1016/j.euf.2023.10.010.
[32]
Watts T, Courtier N, Fry S, et al. Access, acceptance and adherence to cancer prehabilitation: a mixed-methods systematic review[J]. J Cancer Surviv, 2024 May 6. DOI: 10.1007/s11764-024-01605-3.
[33]
王天龙. 推动麻醉前预康复临床实践,实现围术期高质量发展[J]. 临床麻醉学杂志, 2024, 40(2): 117-118. DOI:10.12089/jca.2024.02.001.
[34]
Levett DH, Jack S, Swart M, et al. Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation[J]. Br J Anaesth, 2018, 120(3): 484-500. DOI: 10.1016/j.bja.2017.10.020.
[35]
Bull FC, Al-Ansari SS, Biddle S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour[J]. Br J Sports Med, 2020, 54(24): 1451-1462. DOI: 10.1136/bjsports-2020-102955.
[36]
Blackwell JM, Doleman B, Boereboom CL, et al. High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial[J]. Prostate Cancer Prostatic Dis, 2020, 23(4): 696-704. DOI: 10.1038/s41391-020-0219-1.
[37]
Singh F, Newton RU, Taaffe DR, et al. Prehabilitative versus rehabilitative exercise in prostate cancer patients undergoing prostatectomy[J]. J Cancer Res Clin Oncol, 2023, 149(18): 16563-16573. DOI: 10.1007/s00432-023-05409-3.
[38]
Jensen BT, Jensen JB, Love-Retinger N, et al. Implementing a multimodal prehabilitation program to radical cystectomy in a comprehensive cancer center: a pilot study to assess feasibility and outcomes[J]. Urol Nurs, 2019, 39(6): 303-313. DOI: 10.7257/1053-816x.2019.39.6.303.
[39]
中华医学会肠外肠内营养学分会, 中国医药教育协会加速康复外科专业委员会. 加速康复外科围术期营养支持中国专家共识(2019版)[J]. 中华消化外科杂志, 2019, 18(10): 897-902. DOI: 10.3760/cma.j.issn.1673-9752.2019.10.001.
[40]
Ritch CR, CooRson MS, Clark PE, et al. Perioperative oral nutrition supplementation reduces prevalence of sarcopenia following radical cystectomy: results of a prospective randomized controlled trial[J]. J Urol, 2019, 201(3): 470-477. DOI: 10.1016/j.juro.2018.10.010.
[41]
Hamilton-Reeves JM, Bechtel MD, Hand LK, et al. Effects of immunonutrition for cystectomy on immune response and infection rates: a pilot randomized controlled clinical trial[J]. Eur Urol, 2016, 69(3): 389-392. DOI: 10.1016/j.eururo.2015.11.019.
[42]
Mundle R, Afenya E, Agarwal N. The effectiveness of psychological intervention for depression, anxiety, and distress in prostate cancer: a systematic review of literature[J]. Prostate Cancer Prostatic Dis, 2021, 24(3): 674-687. DOI: 10.1038/s41391-021-00342-3.
[43]
Lemiński A, Kaczmarek K, Bańcarz A, et al. Educational and psychological support combined with minimally invasive surgical technique reduces perioperative depression and anxiety in patients with bladder cancer undergoing radical cystectomy[J]. Int J Environ Res Public Health, 2021, 18(24): 13071. DOI: 10.3390/ijerph182413071.
[44]
Ilie G, Rendon R, Mason R, et al. A comprehensive 6-mo prostate cancer patient empowerment program decreases psychological distress among men undergoing curative prostate cancer treatment: a randomized clinical trial[J]. Eur Urol, 2023, 83(6): 561-570. DOI: 10.1016/j.eururo.2023.02.009.
[45]
Minnella EM, Awasthi R, Bousquet-Dion G, et al. Multimodal prehabilitation to enhance functional capacity following radical cystectomy: a randomized controlled trial[J]. Eur Urol Focus, 2021, 7(1): 132-138. DOI: 10.1016/j.euf.2019.05.016.
[46]
Ploussard G, Almeras C, Beauval JB, et al. A combination of enhanced recovery after surgery and prehabilitation pathways improves perioperative outcomes and costs for robotic radical prostatectomy[J]. Cancer, 2020, 126(18): 4148-4155. DOI: 10.1002/cncr.33061.
[47]
Rahota RG, Salin A, Gautier JR, et al. A prehabilitation programme implemented before robot-assisted radical prostatectomy improves peri-operative outcomes and continence recovery[J]. BJU Int, 2022, 130(3): 357-363. DOI: 10.1111/bju.15666.
[48]
Del Bianco N, Borsati A, Toniolo L, et al. What is the role of physical exercise in the era of cancer prehabilitation?A systematic review[J]. Crit Rev Oncol Hematol, 2024, 198: 104350. DOI: 10.1016/j.critrevonc.2024.104350.
[49]
Blackwell JEM, Gharahdaghi N, Deane CS, et al. Molecular mechanisms underpinning favourable physiological adaptations to exercise prehabilitation for urological cancer surgery[J]. Prostate Cancer Prostatic Dis, 2023, 27(4): 749-755. DOI: 10.1038/s41391-023-00774-z.
[50]
Michael CM, Lehrer EJ, Schmitz KH, et al. Prehabilitation exercise therapy for cancer: a systematic review and meta-analysis[J]. Cancer Med, 2021, 10(13): 4195-4205. DOI: 10.1002/cam4.4021.
[51]
Hall LM, Neumann P, Hodges PW. Do features of randomized controlled trials of pelvic floor muscle training for postprostatectomy urinary incontinence differentiate successful from unsuccessful patient outcomes?A systematic review with a series of meta-analyses[J]. Neurourol Urodyn, 2020, 39(2): 533-546. DOI: 10.1002/nau.24291.
[52]
Khaleel S, Regmi S, Hannah P, et al. Impact of preoperative immunonutrition on perioperative outcomes following cystectomy[J]. J Urol, 2021, 206(5): 1132-1138. DOI: 10.1097/JU.0000000000001945.
[53]
Aldhaam NA, Elsayed AS, Hussein AA, et al. Impact of perioperative multidisciplinary rehabilitation pathway on early outcomes after robot-assisted radical cystectomy: a matched analysis[J]. Urology, 2021, 147: 155-161. DOI: 10.1016/j.urology.2020.05.113.
[54]
Daniels SL, Lee MJ, George J, et al. Prehabilitation in elective abdominal cancer surgery in older patients: systematic review and meta-analysis[J]. BJS Open, 2020, 4(6): 1022-1041. DOI: 10.1002/bjs5.50347.
[55]
张蕊, 夏露, 吴美, 等. 老年早期肺癌患者术前预康复感知的质性研究[J]. 护理学杂志, 2024, 39(2): 19-22. DOI: 10.3870/j.issn.1001-4152.2024.02.019.
[56]
Tang CY, Turczyniak M, Sayner A, et al. Adopting a collaborative approach in developing a prehabilitation program for patients with prostate cancer utilising experience-based co-design methodology[J]. Support Care Cancer, 2020, 28(11): 5195-5202. DOI: 10.1007/s00520-020-05341-z.
[57]
Smyth E, Brennan L, Enright R, et al. The acceptability of exercise prehabilitation before cancer surgery among patients, family members and health professionals: a mixed methods evaluation[J]. Support Care Cancer, 2024, 32(6): 399. DOI: 10.1007/s00520-024-08574-4.
[58]
王雅阁, 邱英. 快速康复外科模式下膀胱肿瘤根治性切除术患者出院准备度及其影响因素分析[J]. 现代泌尿生殖肿瘤杂志, 2023, 15(5): 301-305, 312. DOI: 10.3870/j.issn.1674-4624.2023.05.010.
[59]
van der Velde M, van der Leeden M, Geleijn E, et al. What moves patients to participate in prehabilitation before major surgery?A mixed methods systematic review[J]. Int J Behav Nutr Phys Act, 2023, 20(1): 75. DOI: 10.1186/s12966-023-01474-6.
[1] 中国医疗保健国际交流促进会临床营养健康学分会, 中华医学会肠外肠内营养学分会, 中国营养学会临床营养分会, 中国医师协会营养医师专业委员会. 肠外营养中电解质补充中国专家共识(2024版)[J/OL]. 中华普通外科学文献(电子版), 2025, 19(02): 73-84.
[2] 刘伟博, 李林, 张玉斌. ERAS理念下的经脐单孔腹腔镜胆囊切除术对患者术后恢复的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(03): 278-281.
[3] 顾慧萍, 岑雨琦, 张钱萍, 牛丽妍, 许敏, 陈颖萍, 邹翔宇, 冯升. 小儿泌尿外科全麻术后家长参与式早期进水进食的研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 53-57.
[4] 杨洋, 张晓贝, 曹栋, 张建岭, 俞永江. 接受抗血栓治疗老年患者行腹腔镜腹股沟疝修补术安全性评价[J/OL]. 中华疝和腹壁外科杂志(电子版), 2025, 19(03): 269-275.
[5] 卢飞飞, 王隽, 江志伟, 冯秀梅, 权红光, 刘静. 纳布啡联合罗哌卡因超声引导髂腹下/髂腹股沟神经阻滞对腹股沟疝术后疼痛及早期恢复的影响[J/OL]. 中华疝和腹壁外科杂志(电子版), 2025, 19(03): 296-300.
[6] 马慧, 孟伊雯, 曹佳, 李绍杰, 唐健雄, 顾芬. 术前预康复在腹壁切口疝患者中的应用[J/OL]. 中华疝和腹壁外科杂志(电子版), 2025, 19(03): 306-310.
[7] 毛姗姗, 王隽, 胡蕊, 冯秀梅, 卢飞飞. 经皮穴位电刺激复合腹横肌平面阻滞在腹腔镜经腹腹膜前疝修补术中的应用[J/OL]. 中华疝和腹壁外科杂志(电子版), 2025, 19(01): 74-78.
[8] 李少萍, 徐叶, 陈焕玲, 陈丹. 基于加速康复外科理念的护理干预对老年腹股沟疝修补术后疼痛的影响[J/OL]. 中华疝和腹壁外科杂志(电子版), 2025, 19(01): 99-103.
[9] 邱雨豪, 黄金向, 朱小轩, 罗峰, 黄河, 姚晖, 汪雪. 多学科诊疗联合加速康复外科模式在食管裂孔疝诊疗中的应用[J/OL]. 中华疝和腹壁外科杂志(电子版), 2025, 19(01): 56-62.
[10] 林建琴, 孔令敏, 陆银凤, 陈勇, 金凤, 叶磊, 陈方梅. PERMA模式对肺癌患者治疗获益感及生活质量的影响分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 634-638.
[11] 赵畅, 杨毅, 唐华勇, 肖群, 袁通立. 三镜联合与双镜联合治疗胆囊结石合并胆总管结石的临床疗效比较[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(03): 408-415.
[12] 杜文成, 黄若楠, 孙翀, 李瑞, 徐成臣, 胡开泰, 崔磊, 王辉, 谢应海. ERAS理念在老年腹腔镜联合胆道镜胆总管切开取石一期缝合患者中的应用[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(03): 416-422.
[13] 冯嘉楠, 蔡磊, 何国林, 付顺军, 张成, 冯周彬, 温耀鸿, 谭洪坤, 潘明新. 腹腔镜胆总管切开探查取石一期缝合的安全性与疗效:附128例分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 543-550.
[14] 龚财芳, 赵俊宇, 游川. 围手术期肠内营养在肝癌肝切除患者中有效性及安全性的Meta分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 551-556.
[15] 朱志, 张鑫炜, 谭文斐, 高梓茗, 赵睿涵, 杨野, 王世洋, 智冬梅, 赵鑫, 尹长欣, 高畅远, 王锡山, 王振宁, 李凯, 周海涛. 直肠癌经自然腔道取标本手术在日间手术中的应用[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(04): 329-334.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?