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中华腔镜泌尿外科杂志(电子版) ›› 2026, Vol. 20 ›› Issue (05) : 588 -593. doi: 10.3877/cma.j.issn.1674-3253.2026.05.015

综述

富血小板血浆治疗间质性膀胱炎研究进展
常景宇1, 方广利2, 邱志磊2,()   
  1. 1266000 山东,青岛大学
    2266000 山东,青岛市市立医院泌尿外科
  • 收稿日期:2025-07-21 出版日期:2026-10-01
  • 通信作者: 邱志磊
  • 基金资助:
    山东省医药卫生科技项目(202304050445)

Advances in platelet-rich plasma therapy for interstitial cystitis

Jingyu Chang1, Guangli Fang2, Zhilei Qiu2,()   

  1. 1Qingdao University, Qingdao 266000, China
    2Department of Urology, Qingdao Municipal Hospital, Qingdao 266000, China
  • Received:2025-07-21 Published:2026-10-01
  • Corresponding author: Zhilei Qiu
引用本文:

常景宇, 方广利, 邱志磊. 富血小板血浆治疗间质性膀胱炎研究进展[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2026, 20(05): 588-593.

Jingyu Chang, Guangli Fang, Zhilei Qiu. Advances in platelet-rich plasma therapy for interstitial cystitis[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2026, 20(05): 588-593.

间质性膀胱炎(IC)或膀胱疼痛综合征(BPS),是一种以膀胱或盆腔疼痛、尿频、尿急为特征的慢性疾病,通常无明确感染证据,其发病机制复杂,病因尚未明确。目前临床治疗以行为干预、药物和微创手术为主,但缺乏持久疗效。近年来,富血小板血浆(PRP)作为一种再生医学疗法,通过膀胱黏膜下注射、膀胱灌注显示出显著疗效。PRP通过促进尿路上皮愈合、减轻膀胱神经性疼痛、抗菌作用,为IC提供了安全有效的治疗选择,尤其适用于常规治疗无效患者,目前已有多所医院开展临床治疗。本文主要阐述PRP的主要成分、制备、作用机制以及PRP治疗IC的现状。

Interstitial cystitis (IC) is also known as bladder pain syndrome (BPS), which is a chronic condition characterized by bladder or pelvic pain, urinary frequency, and urgency, typically without evidence of infection. Its pathogenesis is complex and remains unclear. Current clinical treatments primarily involve behavioral interventions, medications, and minimally invasive surgeries, but long-term efficacy remains limited. In recent years, platelet-rich plasma (PRP), a regenerative medicine therapy, has demonstrated significant efficacy through submucosal bladder injections or intravesical instillation. PRP promotes urothelial healing, alleviates bladder neuropathic pain, and exerts antibacterial effects, offering a safe and effective treatment option for IC patients unresponsive to conventional therapies. Multiple hospitals have now adopted PRP in clinical practice. This article elaborates on the key components, preparation methods, the mechanisms of PRP action, and the current status of PRP therapy for IC.

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