探讨间质性膀胱炎（IC）患者膀胱组织中神经纤维密度与尿流动力学的相关性，明确其在IC发病机制中的作用。

选取自2013年6月至2016年3月的43例IC患者，均进行盆腔疼痛和尿频尿急症状评分（PUF）、疼痛视觉模拟评分（VAS）、尿流动力学检查膀胱组织行PGP9.5单克隆抗体免疫组化和神经纤维计数。

尿频评分为（2.8±0.9）分，尿急评分为（2.1±0.8）分，VAS评分为（6.2±2.7）分。最大尿流率、膀胱初感觉容量、初急迫容量、强烈急迫容量、膀胱最大容量、排尿期最大逼尿肌压分别为（18±4） ml/L、（128±57） ml、（163±59） ml、（208±86） ml、（226±94） ml、（33±7） cmH₂O。神经纤维密度平均为（5.2±2.2）条/cm²。神经纤维密度分别与尿频、尿急、疼痛评分呈正相关，与膀胱初感觉容量、初急迫容量、强烈急迫容量、膀胱最大容量呈负相关。

膀胱组织神经纤维密度与膀胱初感觉容量、初急迫容量、强烈急迫容量、膀胱最大容量呈负相关，提示神经纤维密度增高在IC的发病机制中起重要作用。

To investigate the relationship of nerve fiber density in bladder tissues and urodynamic tests in patients with interstitial cystitis(IC), in order to understand its role in the pathogenesis of IC.

The group included 43 cases of IC patients. All cases accepted pelvic pain and urinary urgency frequgency (PUF) and visual analogue score (VAS), pain scores, urodynamic tests, immunohistochemistry of the PGP9.5 monoclonal antibody and nerve fiber counting were performed in bladder tissues.

The urinary frequgency, urgency and VAS scores were (2.8±0.9), (2.1±0.8), (6.2±2.7) respectively. The maximum flow rate, first sensation, first desire to void, strong desire to void, maximum cystometric capacity, max detrusor pressure were (18±4) ml/L, (128±57) ml, (163±59)ml, (208±86) ml, (226±94) ml, (33±7) cmH₂O respectively. The nerve fiber density of the bladder tissue in the group was (5.2±2.2)/cm².

The density of nerve fibers in bladder tissues of IC has a positive relationship with the urinary frequgency, urgency and VAS scores, and it has a negative relationship with the first sensation, first desire to void, strong desire to void, maximum cystometric capacity, which suggestes that high expression of nerve fibers in bladder tissues may play an important role in the pathogenesis of IC.