探讨膀胱副神经节瘤（PUB）的临床病理特征及诊断治疗方法。

回顾性分析2007年11月至2018年7月我院收治的6例膀胱副神经节瘤患者临床资料，总结分析膀胱副神经节瘤的临床病理特点和诊治要点。

6例患者中男性1例，女性5例，平均年龄42（23～55）岁，所有患者均为无功能性肿瘤，1例临床表现为尿痛，5例为体检发现膀胱占位。CT增强扫描明显强化。肿瘤均为单发，平均直径1.6（0.8～2.2）cm。1例行腹腔镜膀胱部分切除术，1例行膀胱部分切除术，4例行经尿道膀胱肿瘤电切术。平均手术时间72（35～130）min，平均估计出血量22（10～50） ml。术后病理6例均有阳性表达神经内分泌标志物CgA、CD56和Syn，而上皮性标志物如CK、CEA等为阴性。术后随访8个月至11年，1例于经尿道膀胱肿瘤电切术（TURBT）术后5年复发，其余5例均无肿瘤复发或转移。

膀胱副神经节瘤临床罕见，可无明显症状，CT增强扫描结合免疫组化检测可明确诊断，经尿道膀胱肿瘤电切术安全、有效，术后需长期随访。

To investigate the clinicopathological features, diagnosis and treatment of paraganglioma of urinary bladder (PUB).

The clinicopathological and follow-up data of 6 patients with paraganglioma of urinary bladder treated during November 2008 and July 2018 in our hospital were retrospectively analyzed.

The six cases involved 1 males and 5 females with the average age of 42 (23-55) years. All cases were nonfunctional neoplasm. All the lesions were solitary with an average diameter of 1.6 (0.8-2.2) cm. One case had the symptom of urodynia, the other 5 cases were asymptomatic. CT scan was significantly enhanced. One case underwent laparoscopic partial cystectomy, one case underwent partial cystectomy, and the other 4 cases underwent transurethral resection of bladder tumor (TURBT). The average duration of operation was 72 (35-130) min. The average estimated blood loss was 22 (10-50) ml. Immunohistochemistry showed neuroendocrine markers (e.g. CgA, CD56 and Syn) were expressed in all cases, while epithelial markers (e.g. CK, CEA) were negative. During the follow-up of 8 months to 11 years, one patient suffered from recurrent tumor 5 years after initial TURBT. The other five cases had no recurrence or metastasis.

PUB is a rare tumor which has no obvious symptoms. A definite diagnosis can be made by CT scan combined with immunohistochemistry. TURBT was safe and effective. The life-long follow-up of these lesions was indispensable.