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中华腔镜泌尿外科杂志(电子版) ›› 2024, Vol. 18 ›› Issue (02) : 183 -187. doi: 10.3877/cma.j.issn.1674-3253.2024.02.013

综述

膀胱小细胞癌发病机制及其诊疗研究进展
谭智勇1, 付什1, 李宁1, 王海峰1, 王剑松1,()   
  1. 1. 650101 云南,昆明医科大学第二附属医院泌尿外科
  • 收稿日期:2022-11-22 出版日期:2024-04-01
  • 通信作者: 王剑松
  • 基金资助:
    国家自然科学基金(82060464); 云南省教育厅科研基金项目(2022Y221)

Research progress on the pathogenesis and diagnosis and treatment of small cell carcinoma of the bladder

Zhiyong Tan, Shi Fu, Ning Li   

  • Received:2022-11-22 Published:2024-04-01
引用本文:

谭智勇, 付什, 李宁, 王海峰, 王剑松. 膀胱小细胞癌发病机制及其诊疗研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(02): 183-187.

Zhiyong Tan, Shi Fu, Ning Li. Research progress on the pathogenesis and diagnosis and treatment of small cell carcinoma of the bladder[J]. Chinese Journal of Endourology(Electronic Edition), 2024, 18(02): 183-187.

膀胱癌(bladder cancer,BCa)是泌尿系常见的恶性肿瘤,其病死率在全球呈逐年上升趋势,每年约有43万例患者被诊断为BC,并且每年导致约165 000例患者死亡[1]。BC最常见的组织学类型是尿路上皮癌,约占90%以上,而鳞状细胞癌、腺癌以及肉瘤相对少见[2]。神经内分泌癌来源于神经内分泌细胞,根据形态其可分为类癌、不典型类癌、小细胞癌和大细胞癌,其中来源于肺的最为常见,而膀胱小细胞癌(small cell carcinoma of bladder,SCCB)非常罕见,约占所有膀胱恶性肿瘤的0.5%~1.0%,超过一半的SCCB伴尿路上皮癌浸润[3]。与膀胱尿路上皮癌类似,SCCB多见于70岁左右的老年男性,男女比例约为3∶1,且患病者多有吸烟史。此外,膀胱结石、慢性膀胱炎等也是其发病的独立危险因素,SCCB与种族有一定相关性,白种人与非白种人比例约为10∶1[4]。由于SCCB缺乏特异的临床表现,病例数较少,目前国内外对于SCCB的诊治尚未形成规范、统一的方案。本文就近年来SCCB的研究进展进行综述,为更好地理解SCCB的发病机制以及在临床上采取更佳的治疗策略提供参考。

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