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中华腔镜泌尿外科杂志(电子版) ›› 2024, Vol. 18 ›› Issue (04) : 361 -365. doi: 10.3877/cma.j.issn.1674-3253.2024.04.010

临床研究

尿酸结石的危险因素分析及双能量CT特征研究
江杰1, 沈城1, 潘永昇1, 陈新风1, 刘振民1, 朱华1,(), 郑兵1   
  1. 1. 226001 江苏,南通大学第二附属医院泌尿外科
  • 收稿日期:2022-10-09 出版日期:2024-08-01
  • 通信作者: 朱华
  • 基金资助:
    南通市卫健委科研课题(MB2021025); 南通市"十四五"科教强卫工程(重点57); 南通市科技计划项目(M'S22022085)

Analysis of risk factors and dual-energy CT features of uric acid calculi

Jie Jiang1, Cheng Shen1, Yongsheng Pan1, Xinfeng Chen1, Zhenmin Liu1, Hua Zhu1,(), Bing Zheng1   

  1. 1. Department of Urology, The Second Affiliated Hospital of Nantong University, Jiangsu 226001, China
  • Received:2022-10-09 Published:2024-08-01
  • Corresponding author: Hua Zhu
引用本文:

江杰, 沈城, 潘永昇, 陈新风, 刘振民, 朱华, 郑兵. 尿酸结石的危险因素分析及双能量CT特征研究[J]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 361-365.

Jie Jiang, Cheng Shen, Yongsheng Pan, Xinfeng Chen, Zhenmin Liu, Hua Zhu, Bing Zheng. Analysis of risk factors and dual-energy CT features of uric acid calculi[J]. Chinese Journal of Endourology(Electronic Edition), 2024, 18(04): 361-365.

目的

分析尿酸结石患者的临床特征,探讨尿酸结石形成的危险因素及双能量CT预测尿酸结石的价值。

方法

回顾性分析2017年3月至2020年11月于南通大学第二附属医院泌尿外科就就诊的75例尿酸结石患者的临床资料,并将同时期75例无结石病史的体检人群设为对照组,分析比较两组的临床特征,并进一步采用Logistic回归分析尿酸结石形成的危险因素。同时对双能量CT预测尿酸结石的敏感度和特异度进行分析。

结果

与对照组相比,尿酸结石组的男性比例更多、尿液pH更低、尿路感染的可能性更大;血肌酐、血钙、血钠、血尿酸比对照组高;多因素Logistic回归分析显示男性、尿液低pH、高血钙、高血尿酸是尿酸结石形成的危险因素。双能量CT预测尿酸结石的敏感度为97.44%,特异度为100%。

结论

尿酸结石的形成可能与性别、尿液pH、血钙、血尿酸有关;双能量CT可以对尿酸结石进行一定程度的预测。

Objective

To analyze the clinical characteristics of patients with uric acid stones, explore the risk factors for uric acid stone formation, and evaluate the value of dual-energy CT in predicting uric acid stones.

Methods

A retrospective analysis was conducted on the clinical data of 75 patients with uric acid stones who visited the Department of Urology at the Second Affiliated Hospital of Nantong University from March 2017 to November 2020. A control group was set up with 75 healthy individuals who had no history of stones during the same period. The clinical characteristics of the two groups were analyzed and compared, and the risk factors for the formation of uric acid stones were further analyzed using logistic regression. Simultaneously analyze the sensitivity and specificity of dual-energy CT in predicting uric acid stones.

Results

Compared with the control group, the uric acid stone group had a higher proportion of males, lower urine pH, and a higher likelihood of urinary tract infections. Blood creatinine, calcium, sodium, and uric acid were higher in the control group than in the control group. Multivariate Logistic regression analysis showed that male, low urine pH, high blood calcium, and high blood uric acid were risk factors for the formation of uric acid stones. The sensitivity and specificity of dual-energy CT for predicting uric acid stones are 97.44% and 100%, respectively.

Conclusions

The formation of uric acid stones may be related to gender, urine pH, blood calcium, and blood uric acid. Dual-energy CT can predict uric acid stones to a certain extent.

表1 尿酸结石组与无结石病史体检人群(对照组)一般资料比较
表2 尿酸结石组与无结石病史体检人群(对照组)尿常规结果比较
表3 尿酸结石组与无结石病史体检人群(对照组)生化代谢指标比较
表4 尿酸结石形成的多因素Logistic回归分析
图1 三组血尿酸浓度比较注:对照组为无结石病史的体检人群,尿酸结石组血尿酸浓度均高于对照组(P<0.001)
表5 双能量CT预测尿酸结石的敏感度及特异度(例)
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