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中华腔镜泌尿外科杂志(电子版) ›› 2025, Vol. 19 ›› Issue (01) : 111 -115. doi: 10.3877/cma.j.issn.1674-3253.2025.01.019

病例报告

原发性输尿管小细胞神经内分泌癌一例报告并文献复习
蒋爽1, 张昊1,()   
  1. 1.110001 沈阳,中国医科大学附属第一医院泌尿外科
  • 收稿日期:2022-12-20 出版日期:2025-02-01
  • 通信作者: 张昊
  • 基金资助:
    辽宁省自然科学基金(2022-MS-190)

Primary small cell neuroendocrine carcinoma of the ureter: a case report and literature review

Shuang Jiang1, Hao Zhang1,()   

  1. 1.Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China
  • Received:2022-12-20 Published:2025-02-01
  • Corresponding author: Hao Zhang
引用本文:

蒋爽, 张昊. 原发性输尿管小细胞神经内分泌癌一例报告并文献复习[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 111-115.

Shuang Jiang, Hao Zhang. Primary small cell neuroendocrine carcinoma of the ureter: a case report and literature review[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2025, 19(01): 111-115.

目的

探讨原发性输尿管小细胞神经内分泌癌的病因、病理特点、诊断及治疗。

方法

回顾性分析中国医科大学附属第一医院收治的1例原发性输尿管小细胞神经内分泌癌患者的临床资料,并结合现有文献,总结该疾病的诊治方法。

结果

患者行腹腔镜下右肾、输尿管及部分膀胱切除术,术后病理结果提示为低分化小细胞神经内分泌癌,患者行6次依托泊苷联合卡铂化疗后,髂血管旁复发,同时出现多发骨转移,将患者化疗方案改为多西他赛联合卡培他滨方案并加用阿帕替尼,肿瘤仍旧发生进展,最终患者死亡。

结论

原发性输尿管小细胞神经内分泌癌是一种罕见的泌尿系恶性肿瘤,确诊方法主要依靠于病理结果,因其极低的发病率,目前尚无统一的治疗规范,预后极差。

Objective

To analyze the etiology,pathology, diagnosis and treatment of ureteral small cell neuroendocrine carcinoma.

Methods

The data of one patient who was diagnosed as urethral small cell neuroendocrine carcinoma were analyzed retrospectively, and literatures were reviewed to summarize the diagnosis and treatment of this disease.

Results

After laparoscopic radical resection of ureteral carcinoma, the pathology was diagnosed as small cell neuroendocrine carcinoma of ureter. After 6 cycles of Etoposide combined with Carboplatin chemotherapy, the patient recurrence, and showed bone metastasis. After 1 cycle of Docetaxel combined with Capecitabine and Apatinib, the patient finally died.

Conclusions

Ureteral small cell neuroendocrine carcinoma with urethral cell components is a rare urinary system cancer with poor clinical prognosis, and the diagnosis depends on the pathology.

图1 复发性小细胞神经内分泌癌患者泌尿系增强CTU结果(R示肿瘤)
图2 复发性小细胞神经内分泌癌患者肿瘤大体标本
图3 复发性小细胞神经内分泌癌患者肿瘤病理HE染色及免疫组化(×400) 注:a为HE染色,b示免疫组化CD56(++),c示SYN(部分+),d示CgA(部分+)
图4 原发性小细胞神经内分泌癌6次EC(依托泊苷+卡铂)化疗后患者全腹CT(箭头示肿物)
表1 近5年小细胞神经内分泌癌相关文献总结
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