切换至 "中华医学电子期刊资源库"

中华腔镜泌尿外科杂志(电子版) ›› 2023, Vol. 17 ›› Issue (01) : 44 -49. doi: 10.3877/cma.j.issn.1674-3253.2023.01.010

临床研究

等离子电切术与钬激光剜除术治疗体积>80 ml前列腺增生的比较
游猛1, 顾志文1,(), 宋生生1, 张贺庆1, 詹河涓1   
  1. 1. 528031 广东,佛山市复星禅诚医院泌尿外科
  • 收稿日期:2022-09-21 出版日期:2023-02-01
  • 通信作者: 顾志文
  • 基金资助:
    佛山市科技创新项目自筹经费类科技计划项目(1920001001596)

Comparison of transurethral bipolar plasmakinetic prostatectomy and holmium laser enucleation of the prostate for the treatment of large-size benign prostatic hyperplasia: a randomized controlled study

Meng You1, Zhiwen Gu1,(), Shengsheng Song1, Heqing Zhang1, Hejuan Zhan1   

  1. 1. Department of Urology, Foshan Fosun Chancheng Hospital, Guangdong 528031, China
  • Received:2022-09-21 Published:2023-02-01
  • Corresponding author: Zhiwen Gu
引用本文:

游猛, 顾志文, 宋生生, 张贺庆, 詹河涓. 等离子电切术与钬激光剜除术治疗体积>80 ml前列腺增生的比较[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(01): 44-49.

Meng You, Zhiwen Gu, Shengsheng Song, Heqing Zhang, Hejuan Zhan. Comparison of transurethral bipolar plasmakinetic prostatectomy and holmium laser enucleation of the prostate for the treatment of large-size benign prostatic hyperplasia: a randomized controlled study[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2023, 17(01): 44-49.

目的

比较经尿道前列腺等离子双极电切术(TUPKP)与经尿道前列腺钬激光剜除术(HoLEP)治疗体积>80 ml前列腺增生(BPH)的安全性及疗效。

方法

纳入佛山复星禅诚医院泌尿外科2017年1月至2021年1月收治的80例前列腺体积>80 ml的前列腺增生患者,按随机数字法将其分为TUPKP组、HoLEP组,剔除失访病例,两组顺利完成研究的分别有37例、35例,记录两组术前及术后IPSS、QOL、Qmax、RUV、手术时间、术中出血量、术后留置尿管时间、术后住院天数、并发症等。

结果

两组均能一期完成手术,HoLEP组的手术时间、术后留置尿管天数、术后住院天数均明显少于TUPKP组(P<0.05),两组术后膀胱冲洗时间差异无统计学意义(P>0.05);HoLEP组切除的前列腺组织量多于TUPKP组(P<0.05),但手术出血量少于后者(P<0.05)。两组术后1个月、6个月的IPSS、RUV、QOL较术前显著降低(P<0.05),Qmax较术前明显增高(P<0.05);TUPKP组术后1个月的IPSS及QOL改善比HoLEP组更为明显(P<0.05),术后6个月两组的IPSS、Qmax、RUV及QOL差异无统计学意义(P>0.05)。两组术中、术后并发症发生率差异无统计学意义(P>0.05)。

结论

HoLEP和TUPKP均可应用于大体积前列腺增生的治疗,两者均安全有效,在处理大体积前列腺时,HoLEP比TUPKP手术效率更高,术中出血量更少,术后留置尿管时间更短,患者能够更早康复出院。

Objective

To compare the safety and efficacy between transurethral bipolar plasmakinetic prostatectomy (TUPKP) and holmium laser enucleation of the prostate (HoLEP) for the treatment of large-size (>80 ml) BPH.

Methods

In Foshan Fosun Chancheng Hospital, from January 2017 to January 2021, patients of BPH, prostate size >80 ml, were enrolled in this randomised controlled study, which were classified as TUPKP group (37 patients) and HoLEP group (35 patients). IPSS, QOL, Qmax and RUV were assessed preoperatively and postoperatively at 1 and 6 months between the two groups. Operative time, blood loss, catheterization duration, postoperative hospital stay and complications were all recorded.

Results

Surgeries were successfully achieved in one stage in all patients. Perioperative results showed that operative time was significantly shorter in HoLEP group as well as catheterization duration and postoperative hospital stay (P<0.05, respectively), while there was no statistical difference between the two groups in terms of postoperative bladder irrigation. The prostate tissue removed in the HoLEP group was more than that in the TUPKP group (P<0.05), and the blood loss was less in the HoLEP group (P<0.05). The IPSS, RUV and QOL in each group at 1 month and 6 months were significantly lower than those before operation (P<0.05), meanwhile, Qmax of the two groups were significantly higher than those before operation (P<0.05). The improvement of IPSS and QOL were more obvious at 1 month in the HoLEP group (P<0.05, respectively). However, there were no significant difference between the two groups in IPSS, Qmax, RUV and QOL at 6 months (P>0.05). There was no significant difference in the incidence of intraoperative and postoperative complications between the two groups (P>0.05).

Conclusions

HoLEP and TUPKP are both safe and effective for the treatment of large-size benign prostatic hyperplasia. Compared to TUPKP, HoLEP provides a superior operative efficiency and bleeding control, it needs shorter catheterization duration and hospital stay.

表1 两组前列腺增生患者术前一般资料比较
表2 两组前列腺增生患者术中、术后情况的比较[M(min~max)]
表3 两组前列腺增生患者手术疗效相关指标的比较[M(min~max)]
表4 两组前列腺增生患者手术并发症的比较[例(%)]
[1]
游猛, 郑彬, 陈岳, 等. 基层医院耻骨上经膀胱和经尿道切除大体积前列腺的比较[J]. 中华腔镜泌尿外科杂志(电子版), 2018, 12(2): 94-97.
[2]
Kotov SV, Surenkov DN, Akritidi AA, et al. Holmium laser enucleation of the prostate-new gold standard of surgical treatment of bph in moscow[J]. Am J Clin Exp Urol, 2020, 13(5): 64-71.
[3]
黄健, 王建亚, 孔垂泽, 等. 中国泌尿外科和男科疾病诊断治疗指南[M]. 北京: 科学出版社, 2019: 210.
[4]
卜小斌, 徐虎. 不同体积良性前列腺增生对经尿道前列腺电切术疗效的影响[J]. 临床医学研究与实践, 2018, 3(6): 68-69.
[5]
Alexander CE, Scullion MM, Omar MI, et al. Bipolar versus monopolar transurethral resection of the prostate for lower urinary tract symptoms secondary to benign prostatic obstruction[J]. Cochrane database of systematic reviews (Online), 2019, 12(12): CD009629.
[6]
熊文清, 万建, 付明. 经尿道前列腺等离子双极电切术治疗大体积良性前列腺增生症疗效观察[J]. 临床外科杂志, 2015, 23(10): 789-791.
[7]
Gilling P, Cass CB, Cresswell MD, et al. Holmium laser resection of the prostate: Preliminary results of a new method for the treatment of benign prostatic hyperplasia[J]. Urology, 1996, 47(1): 48-51.
[8]
Whiting D, Guest K, Penev B, et al. Holmium laser enucleation of the prostate is effective and safe in all prostate sizes[C]. Eur Urol Suppl, 2018, 17(2): e185-e186
[9]
朱清毅, 顾晓箭, 袁琳, 等. 经尿道前列腺等离子切除和钬激光剜除术治疗大体积良性前列腺增生(>80 ml)[J].中华男科学杂志, 2008, 14(10): 907-910.
[10]
刘航, 朱瑞, 唐富强, 等. HoLEP与TUPKP治疗不同体积良性前列腺增生的疗效及安全性研究[J]. 重庆医学, 2020, 49(13): 2121-2126.
[11]
Habib E, Abdallah MF, Elsheemy MS, et al. Holmium laser enucleation versus bipolar resection in the management of large-volume benign prostatic hyperplasia: A randomized controlled trial[J]. Int J Urol, 2022, 29(2): 128-135.
[12]
Lwin AA, Zeng JP, Evans P, et al. Holmium Laser Enucleation of the Prostate Is Safe and Feasible as a Same Day Surgery[J]. Urology, 2020, 138: 119-124.
[13]
Enikeev DV, Glybochko PV, Alyaev YG, et al. Laser enucleation of the prostate (holep and thulep): a comparative effectiveness analysis in treating recurrent prostatic hyperplasia[J]. Urologiya (Moscow), 2017, (4): 50-54.
[14]
严滴石, 刘正超, 郑俊, 等. 绿激光剜除术和经尿道电切术治疗大体积前列腺增生症的前瞻性随机对照研究[J]. 第三军医大学学报, 2021, 43(3): 255-260.
[15]
龚旻, 伊庆同, 胡巍, 等. 经尿道前列腺电汽化术及等离子电切术后5年疗效随访[J]. 中华泌尿外科杂志, 2012, 33(5): 364-368.
[16]
Fallara G, Capogrosso P, Schifano N, et al. Ten-year Follow-up Results After Holmium Laser Enucleation of the Prostate[J]. Eur Urol Focus, 2021, 7(3): 612-617.
[17]
Elshal AM, Soltan M, El-Tabey NA, et al. Randomised trial of bipolar resection vs holmium laser enucleation vs Greenlight laser vapo-enucleation of the prostate for treatment of large benign prostate obstruction: 3-years outcomes[J]. BJU Int, 2020, 126(6): 731-738.
[18]
邓治林, 蒋炜, 陈勇, 等. 经尿道前列腺电切术中包膜穿孔的临床分析[J]. 中国医师进修杂志, 2011, 34(23): 21-23.
[19]
Kutluev MM, Safiullin RI. Our experience of holmium laser enucleation of the prostate[J]. Urologiia, 2022, (1): 67-71.
[20]
Al-Rawashdah SF, Pastore AL, Al Salhi Y, et al. Prospective randomized study comparing monopolar with bipolar transurethral resection of prostate in benign prostatic obstruction: 36-month outcomes[J]. World J Urol, 2017, 35(10): 1595-1601.
[21]
Ueki H, Takahashi K, Yasufuku T, et al. Is the membranous urethral length related to postoperative urinary incontinence after holmium laser enucleation of the prostate?[J]. Int J Urol, 2020, 27(10): 893-898.
[22]
汪洋, 李志鹏, 王可兵. 经尿道前列腺钬激光剜除术并发症的研究进展[J].中华腔镜泌尿外科杂志(电子版), 2022, 16(1): 93-96.
[1] 李辉, 尉维录, 吴茂林. 经直肠剪切波弹性成像对存在下尿路症状的前列腺病变良恶性的鉴别诊断价值及其影响因素分析[J/OL]. 中华医学超声杂志(电子版), 2023, 20(11): 1193-1198.
[2] 程志刚, 魏辉, 李一波, 韩健, 钟永豪, 王铭, 张文辉, 周传东. 经尿道前列腺剜除术中保留前列腺分叶沟间组织对术后顺行射精功能的保护[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 453-458.
[3] 李想, 郭征, 田洪哲, 李杜, 熊梦瑶, 潘铁军. 1 470 nm半导体激光减容性切除治疗高危前列腺增生的临床研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 448-452.
[4] 莫林键, 杨舒博, 农卫赟, 程继文. 人工智能虚拟数字医师在钬激光前列腺剜除日间手术患教管理中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 318-322.
[5] 杨登科, 蔡明志, 张星星, 胡青, 郭大勇, 高喆, 毕永启, 胡伟. 腹腔镜膀胱颈Y-V成形术与经尿道膀胱颈电切治疗膀胱颈挛缩的比较[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 392-396.
[6] 潘兴赫, 董翔, 杨海洋, 张雪斌, 甘卫东. 超选择性前列腺动脉栓塞治疗伴急性尿潴留的高危高龄前列腺增生[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(03): 237-242.
[7] 曾明辉, 蒋东方, 秦锁炳. 钬激光前列腺剜除术治疗前列腺增生疗效的影响因素[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(02): 157-161.
[8] 汪洋, 李志鹏, 张楠, 何海填, 杨伟锋, 张焕灵, 王可兵. 保护射精技术在前列腺等离子剜除术中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(02): 152-156.
[9] 张铭星, 刘文倩, 王以然, 赵泽恬, 袁欣怡, 丁留成. 江苏地区腹腔镜下前列腺癌根治术后一年夜尿症发生率及相关危险因素多中心回顾性研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(02): 141-145.
[10] 梅鑫, 张世科, 张巧珍, 吴文起. 前列腺增生导致下尿路症状手术时机的研究进展[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(01): 96-99.
[11] 李腾成, 黄群雄, 胡成, 肖恒军, 徐锦斌, 高舜天, 黄展森, 高新, 狄金明. 机器人腹腔镜后入路筋膜内和筋膜外根治性前列腺切除术技术分析[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(01): 12-18.
[12] 李俊涛, 张天佑, 叶雷, 郭强, 吴坚坚, 尧冰, 王德娟, 邱剑光. 保留"尿道系膜"的腹腔镜下前列腺根治性切除术后尿控情况的研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(01): 19-24.
[13] 李俊涛, 张天佑, 叶雷, 郭强, 吴坚坚, 尧冰, 王德娟, 邱剑光. 保留"尿道系膜"的腹腔镜下前列腺根治性切除术后尿控情况的研究[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(01): 19-24.
[14] 熊风, 林辉煌, 陈晓波. 铥激光在泌尿外科中的临床应用及研究进展[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 533-536.
[15] 韩广玮, 申雪晴, 吴涵潇, 曹炎武, 唐黎明. 前列腺增生并轻度尿道狭窄行去外鞘半导体激光汽化剜除与等离子电切的比较[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 490-494.
阅读次数
全文


摘要