切换至 "中华医学电子期刊资源库"

中华腔镜泌尿外科杂志(电子版) ›› 2023, Vol. 17 ›› Issue (06) : 649 -652. doi: 10.3877/cma.j.issn.1674-3253.2023.06.020

所属专题: 总编推荐

综述

上尿路尿路上皮癌术后预防性膀胱灌注化疗的研究进展
汪洋, 李志鹏, 王可兵()   
  1. 518000 广东,深圳市前海蛇口自贸区医院泌尿外科
    650500 云南,昆明医科大学第二附属医院泌尿外科
  • 收稿日期:2022-09-05 出版日期:2023-12-01
  • 通信作者: 王可兵

Research progress on preventive intravesical chemotherapy after surgery for upper urinary tract urothelial carcinoma

Yang Wang, Zhipeng Li, Kebing Wang()   

  • Received:2022-09-05 Published:2023-12-01
  • Corresponding author: Kebing Wang
引用本文:

汪洋, 李志鹏, 王可兵. 上尿路尿路上皮癌术后预防性膀胱灌注化疗的研究进展[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 649-652.

Yang Wang, Zhipeng Li, Kebing Wang. Research progress on preventive intravesical chemotherapy after surgery for upper urinary tract urothelial carcinoma[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2023, 17(06): 649-652.

上尿路尿路上皮癌(upper tract urothelial carcinoma,UTUC)包括肾盂癌和输尿管癌,在欧美国家其发病率较低,约占尿路上皮癌的5%~10%[1-2],在我国其发病率较高,占尿路上皮癌的18%[3]。UTUC标准手术方法是根治性肾输尿管全长切除加膀胱袖套状切除术(radical nephrourotertectomy,RNU),但术后常出现膀胱肿瘤复发,影响预后。膀胱灌注化疗对减少膀胱肿瘤复发具有重要作用,但灌注方案尚未达成统一意见,本文就其研究进展综述如下。

[1]
Roupret M, Babjuk M, Comperat E, et al. European association of urology guidelines on upper urinary tract urothelial cell carcinoma:2015 update[J]. Eur Urol, 2015, 68(5): 868-879.
[2]
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017, 67(1): 7-30.
[3]
廖洪,李汉忠,张玉石. 单中心尿路上皮癌2115例临床特点分析[J]. 中华泌尿外科杂志, 2014, 35(12): 900-904.
[4]
Seisen T, Granger B, Colin P, et al. A Systematic review and meta-analysis of clinicopathologic factors linked to intravesical recurrence after radical nephroureterectomy to treat upper tract urothelial carcinoma[J]. Eur Urol, 2015, 67(6): 1122-1133.
[5]
Xiong G, Yao L, Hong P, et al. Aristolochic acid containing herbs induce gender-related oncological differences in upper tract urothelial carcinoma patients[J]. Cancer Manag Res, 2018, 10(1): 6627-6639.
[6]
Takahashi T, Kakehi Y, Mitsumori K, et al. Distinct microsatellite alterationsin upper urinary tract tumors and subsequent bladder tumors[J]. J Urol, 2001, 165(2): 672-677.
[7]
Hafner C, Knuechel R, Stoehr R, et al. Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies[J].Int J Cancer, 2002, 101(1): 1-6.
[8]
Yamashita S, Ito A, Mitsuzuka K, et al. Clinical implications of intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma[J]. Int J Urol,2016, 23(5): 378-384.
[9]
Chung JH, Song W, Kang M, et al. Conditional intravesical recurrence-free survival rate after radical nephroureterectomy with bladder cuff excision for upper tract urothelial carcinoma[J]. Front Oncol, 2021, 11: 730114.
[10]
Zigeuner RE, Hutterer G, Chromecki T, et al. Bladder tumour development after urothelial carcinoma of the upper urinary tract is related to primary tumour location[J].BJU Int, 2006, 98(6): 1181-1186.
[11]
Narukawa T, Hara T, Arai E, et al. Tumour multifocality andgrade predict intravesical recurrence after nephroureterectomy in patients with upper urinary tract urothelial carcinoma without a history of bladder cancer[J]. Jpn J Clin Oncol, 2015, 45(5): 488-493.
[12]
袁贺佳,吴吉涛,门昌平,等. 后腹腔镜联合经尿道电切镜术后继发膀胱癌的危险因素分析[J/CD]. 中华腔镜泌尿外科杂志(电子版), 2016, 10(4): 226-229.
[13]
Marchioni M, Primiceri G, Cindolo L, et al. Impact of diagnostic ureteroscopy on intravesical recurrence in patients undergoing radical nephroureterectomy for upper tract urothelial cancer: A systematic review and meta-analysis[J]. BJU Int, 2017, 120(3): 313-319.
[14]
Elalouf V, Xylinas E, Klap J, et al. Bladder recurrence after radical nephroureterectomy:predictors and impact on oncological outcomes[J]. Int J Urol, 2013, 20(11): 1078-1083.
[15]
Shigeta K, Kikuchi E, Hagiwara M, et al. Prolonged pneumoperitoneum time is an independent risk factor for intravesical recurrence after laparoscopic radical nephroureterectomy in upper tract urothelial carcinoma[J].Surg Oncol, 2017, 26(1): 73-79.
[16]
Ahmed M, Harraz, Magdy E, et al. Single versus maintenance intravesical chemotherapy for the prevention of bladder recurrence after radical nephroureterectomy for upper tract urothelial carcinoma: a randomized clinical trial[J]. Clin Genitourin Cancer, 2019, 17(6): 1108-1115.
[17]
Yanagi M, Hamasaki T, Akatsuka J, et al. Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma[J]. BMC Urol, 2021, 21(1): 167.
[18]
Sakamoto N, Naito S, Kumazawa J, et al. Prophylactic intravesical instillation of mitomycin C and cytosine arabinoside for prevention of recurrent bladder tumors following surgery for upper urinary tract tumors: a prospective randomized study[J].Int J Urol, 2001, 8(5): 212-216.
[19]
Ito A, Shintaku I, Satoh M, et al. Prospective randomized phase ii trial of a single early intravesical instillation of pirarubicin (thp) in the prevention of bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma: the thp monotherapy study group trial[J]. J Clin Oncol, 2013, 31(11): 1422-1427.
[20]
O'Brien T, Ray E, Singh R, et al. Prevention of bladder tumours after nephroureterectomy for primary upper urinary tract urothelial carcinoma: a prospective, multicentre, randomised clinical trial of a single postoperative intravesical dose of mitomycin C (the ODMIT-C Trial)[J]. Eur Urol, 2011, 60(4): 703-710.
[21]
Wu WJ, Ke HL, Yang YH, et al. Should patients with primary upper urinary tract cancer receive prophylactic intravesical chemotherapy after nephroureterectomy[J].J Urol, 2010, 183(1): 56-61.
[22]
Yuan H, Mao X, Bai Y, et al. The effect of intravesical chemotherapy in the prevention of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: a meta-analysis[J]. J Chemother, 2015, 27(4): 195-200.
[23]
Dobé T, Califano G, von R, et al. Postoperative chemotherapy bladder instillation after radical nephroureterectomy: results of a european survey from the young academic urologist urothelial cancer group[J]. Eur Urol Open, 2020, 22(22): 45-50.
[24]
Michael A, Uhlman MA, Bing MT, et al. Evaluating the safety of intraoperative instillation of intravesical chemotherapy at the time of nephroureterectomy[J]. BMC Urol, 2015, 15(1): 45-51.
[25]
Nadler N, Oedorf K, Jensen J, et al. Intraoperative mitomycin c bladder installation during radical nephroureterectomy is feasible and safe[J]. Eur Urol Open Sci, 2021, 34(34): 41-46.
[26]
黄健,王建业,孔垂泽,等.中国泌尿外科和男科疾病诊断治疗指南[M]. 2019版. 北京: 科学出版社, 2019: 202.
[27]
Wu P, Zhu G, Wei D, et al. Prophylactic intravesical chemotherapy decreases bladder tumor recurrence after nephroureterectomy for primary upper tract urothelial carcinoma: A systematic review and meta-analysis[J]. J BUON, 2015, 20(5): 1229-1238.
[28]
Yuval F, Rashed G, Nirmish S, et al. Intraoperative prophylactic intravesical chemotherapy to reduce bladder recurrence following radical nephroureterectomy[J]. Urol Oncol, 2020, 38(9): 737.e11-737.e16.
[29]
Fan, B, Teng, Q, Sun, M, et al. Assessment of therapeutic benefit and option strategy on intravesical instillation for preventing bladder cancer recurrence after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma[J]. J Oncol, 2022, 1755368.
[30]
Power NE, Izawa J. Comparison of guidelines on non-muscle invasive bladder cancer (EAU, CUA, AUA, NCCN, NICE)[J]. Bladder Cancer, 2016, 2(1): 27-36.
[31]
Long X, Qi L, Zu X, et al. Prevention of recurrent bladder tumors after nephroureterectomy for primary upper urinary tract urothelial carcinoma: an individualized selection strategy based onpatient risk stratification is needed[J]. Urol Int, 2017, 98(3): 312-319.
[32]
Huang Y, Cen J, Liu Z, et al. A comparison of different prophylactic intravesical chemotherapy regimens for bladder cancer recurrence after nephroureterectomy for primary upper tract urothelial carcinomas: a retrospective 2-center study[J].Technol Cancer Res Treat, 2019, 18(1): 1-9.
[33]
Miyake M, Tatsumi Y, Matsumoto H, et al. Outcomes of subsequent non-muscleinvasive bladder cancer treated with intravesical Bacillus Calmette‐Guérin after radical nephroureterectomy for upper urinary tract urothelial carcinoma[J]. BJU Int, 2018, 121(5): 764-773.
[34]
Lu DD, Boorjian SA, Raman JD, et al. Intravesical chemotherapy use after radical nephroureterectomy: A national survey of urologic oncologists[J]. Urol Oncol, 2017, 35(3): 113.e1-e7.
[35]
Metcalfe M, Wagenheim G, Xiao L, et al. Induction and maintenance adjuvant mitomycin c topical therapy for upper tract urothelial carcinoma: tolerability and intermediate term outcomes[J]. J Endourol, 2017, 31(9): 946-953.
[36]
Yoo SH, Jeong CW, Kwak C, et al.Intravesical chemotherapy after radical nephroureterectomy for primary upper tract urothelial carcinoma:asystematic review and network meta-analysis[J]. J Clin Med, 2019, 8(7): 1059.
[37]
Miyamoto K, Ito A, Wakabayashi M, et al. A Phase III trial of a single early intravesical instillation of pirarubicin to prevent bladder recurrence after radical nephroureterectomy for upper tract urothelial carcinoma (JCOG1403, UTUC THP Phase III)[J]. Jpn J Clin Oncol, 2018, 48(1): 94-97.
[38]
吴肖冰,葛力源,戴黎阳,等.上尿路尿路上皮癌术后预防性膀胱灌注化疗的临床意义[J]. 中华泌尿外科杂志, 2017, 38(4): 286-289.
[39]
王安莲,王勋,刘赟,等. 上尿路尿路上皮癌术后膀胱内复发的危险因素及预防性膀胱灌注化疗的意义[J]. 国际泌尿系统杂志, 2019, 39(3): 457-460.
[40]
Fechner G, Pocha K, Schmidt D, et al. Reducing recurrence and costsin superficial bladder cancer: preclinical evaluation of osmotic cytolysis by distilled water vs. mitomycin[J].Int J Clin Pract, 2006, 60(10): 1178-1180.
[41]
Satoshi Y, Shinichi S, Yusuke I, et al. Intravesical irrigation might prevent bladder recurrence in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma[J].Int J Urol, 2019, 26(8): 791-796.
[42]
廖国栋,俞蔚文,张琦,等. 单次与多次膀胱灌注方案对原发性上尿路尿路上皮癌术后预后的影响[J]. 中国临床药理学与治疗学, 2017, 22(4): 461-465.
[1] 洪玮, 叶细容, 刘枝红, 杨银凤, 吕志红. 超声影像组学联合临床病理特征预测乳腺癌新辅助化疗完全病理缓解的价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(06): 571-579.
[2] 王聪, 李云涛, 唐甜甜, 王鑫蕊, 吕鑫, 范志刚. 多基因检测对激素受体阳性、HER-2阴性乳腺癌新辅助化疗疗效预测的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(05): 292-296.
[3] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[4] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[5] 许杰, 李亚俊, 冯义文. SOX新辅助化疗后腹腔镜胃癌D2根治术与常规根治术治疗进展期胃癌的近期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 647-650.
[6] 薛庆, 施赛叶, 徐雅文, 盛夏, 张芹芹. 追踪方法学联合失效模式与效应分析在膀胱灌注化疗患者中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 553-559.
[7] 宋小飞, 巫嘉文, 孙阳. 输尿管开口周围膀胱黏膜预离断联合早期膀胱灌注化疗在上尿路尿路上皮癌根治术中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 479-484.
[8] 莫淇舟, 苏劲, 黄健, 李健维, 李思宁, 柳建军. 智能控压输尿管软镜碎石吸引取石术在直径10~25 mm上尿路结石中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 497-502.
[9] 杨慧, 郭丽娟, 冯晓丹, 李静, 黄成谋, 蔡兴锐, 覃英娇, 王远礼. 非小细胞肺癌铂类药物耐药mi RNA表达特征及预测分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 719-724.
[10] 韩加刚, 王振军. 梗阻性左半结肠癌的治疗策略[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 450-458.
[11] 石阳, 于剑锋, 曹可, 翟志伟, 叶春祥, 王振军, 韩加刚. 可扩张金属支架置入联合新辅助化疗治疗完全梗阻性左半结肠癌围手术期并发症分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 464-471.
[12] 梁轩豪, 李小荣, 李亮, 林昌伟. 肠梗阻支架置入术联合新辅助化疗治疗结直肠癌急性肠梗阻的疗效及其预后的Meta 分析[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 472-482.
[13] 赵磊, 刘文志, 林峰, 于剑, 孙铭骏, 崔佑刚, 张旭, 衣宇鹏, 于宝胜, 冯宁. 深部热疗在改善结直肠癌术后辅助化疗副反应及生活质量中的作用研究[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 488-493.
[14] 张颖, 赵鑫, 陈佳梅, 李雁. 术前化疗对CRS+HIPEC 治疗腹膜假黏液瘤预后影响的meta 分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 826-835.
[15] 蔡晓雯, 李慧景, 丘婕, 杨翼帆, 吴素贤, 林玉彤, 何秋娜. 肝癌患者肝动脉化疗栓塞术后疼痛风险预测模型的构建及验证[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 722-728.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?