切换至 "中华医学电子期刊资源库"

中华腔镜泌尿外科杂志(电子版) ›› 2023, Vol. 17 ›› Issue (06) : 649 -652. doi: 10.3877/cma.j.issn.1674-3253.2023.06.020

综述

上尿路尿路上皮癌术后预防性膀胱灌注化疗的研究进展
汪洋, 李志鹏, 王可兵()   
  1. 518000 广东,深圳市前海蛇口自贸区医院泌尿外科
    650500 云南,昆明医科大学第二附属医院泌尿外科
  • 收稿日期:2022-09-05 出版日期:2023-12-01
  • 通信作者: 王可兵

Research progress on preventive intravesical chemotherapy after surgery for upper urinary tract urothelial carcinoma

Yang Wang, Zhipeng Li, Kebing Wang()   

  • Received:2022-09-05 Published:2023-12-01
  • Corresponding author: Kebing Wang
引用本文:

汪洋, 李志鹏, 王可兵. 上尿路尿路上皮癌术后预防性膀胱灌注化疗的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 649-652.

Yang Wang, Zhipeng Li, Kebing Wang. Research progress on preventive intravesical chemotherapy after surgery for upper urinary tract urothelial carcinoma[J]. Chinese Journal of Endourology(Electronic Edition), 2023, 17(06): 649-652.

上尿路尿路上皮癌(upper tract urothelial carcinoma,UTUC)包括肾盂癌和输尿管癌,在欧美国家其发病率较低,约占尿路上皮癌的5%~10%[1-2],在我国其发病率较高,占尿路上皮癌的18%[3]。UTUC标准手术方法是根治性肾输尿管全长切除加膀胱袖套状切除术(radical nephrourotertectomy,RNU),但术后常出现膀胱肿瘤复发,影响预后。膀胱灌注化疗对减少膀胱肿瘤复发具有重要作用,但灌注方案尚未达成统一意见,本文就其研究进展综述如下。

[1]
Roupret M, Babjuk M, Comperat E, et al. European association of urology guidelines on upper urinary tract urothelial cell carcinoma:2015 update[J]. Eur Urol, 2015, 68(5): 868-879.
[2]
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017, 67(1): 7-30.
[3]
廖洪,李汉忠,张玉石. 单中心尿路上皮癌2115例临床特点分析[J]. 中华泌尿外科杂志, 2014, 35(12): 900-904.
[4]
Seisen T, Granger B, Colin P, et al. A Systematic review and meta-analysis of clinicopathologic factors linked to intravesical recurrence after radical nephroureterectomy to treat upper tract urothelial carcinoma[J]. Eur Urol, 2015, 67(6): 1122-1133.
[5]
Xiong G, Yao L, Hong P, et al. Aristolochic acid containing herbs induce gender-related oncological differences in upper tract urothelial carcinoma patients[J]. Cancer Manag Res, 2018, 10(1): 6627-6639.
[6]
Takahashi T, Kakehi Y, Mitsumori K, et al. Distinct microsatellite alterationsin upper urinary tract tumors and subsequent bladder tumors[J]. J Urol, 2001, 165(2): 672-677.
[7]
Hafner C, Knuechel R, Stoehr R, et al. Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies[J].Int J Cancer, 2002, 101(1): 1-6.
[8]
Yamashita S, Ito A, Mitsuzuka K, et al. Clinical implications of intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma[J]. Int J Urol,2016, 23(5): 378-384.
[9]
Chung JH, Song W, Kang M, et al. Conditional intravesical recurrence-free survival rate after radical nephroureterectomy with bladder cuff excision for upper tract urothelial carcinoma[J]. Front Oncol, 2021, 11: 730114.
[10]
Zigeuner RE, Hutterer G, Chromecki T, et al. Bladder tumour development after urothelial carcinoma of the upper urinary tract is related to primary tumour location[J].BJU Int, 2006, 98(6): 1181-1186.
[11]
Narukawa T, Hara T, Arai E, et al. Tumour multifocality andgrade predict intravesical recurrence after nephroureterectomy in patients with upper urinary tract urothelial carcinoma without a history of bladder cancer[J]. Jpn J Clin Oncol, 2015, 45(5): 488-493.
[12]
袁贺佳,吴吉涛,门昌平,等. 后腹腔镜联合经尿道电切镜术后继发膀胱癌的危险因素分析[J/CD]. 中华腔镜泌尿外科杂志(电子版), 2016, 10(4): 226-229.
[13]
Marchioni M, Primiceri G, Cindolo L, et al. Impact of diagnostic ureteroscopy on intravesical recurrence in patients undergoing radical nephroureterectomy for upper tract urothelial cancer: A systematic review and meta-analysis[J]. BJU Int, 2017, 120(3): 313-319.
[14]
Elalouf V, Xylinas E, Klap J, et al. Bladder recurrence after radical nephroureterectomy:predictors and impact on oncological outcomes[J]. Int J Urol, 2013, 20(11): 1078-1083.
[15]
Shigeta K, Kikuchi E, Hagiwara M, et al. Prolonged pneumoperitoneum time is an independent risk factor for intravesical recurrence after laparoscopic radical nephroureterectomy in upper tract urothelial carcinoma[J].Surg Oncol, 2017, 26(1): 73-79.
[16]
Ahmed M, Harraz, Magdy E, et al. Single versus maintenance intravesical chemotherapy for the prevention of bladder recurrence after radical nephroureterectomy for upper tract urothelial carcinoma: a randomized clinical trial[J]. Clin Genitourin Cancer, 2019, 17(6): 1108-1115.
[17]
Yanagi M, Hamasaki T, Akatsuka J, et al. Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma[J]. BMC Urol, 2021, 21(1): 167.
[18]
Sakamoto N, Naito S, Kumazawa J, et al. Prophylactic intravesical instillation of mitomycin C and cytosine arabinoside for prevention of recurrent bladder tumors following surgery for upper urinary tract tumors: a prospective randomized study[J].Int J Urol, 2001, 8(5): 212-216.
[19]
Ito A, Shintaku I, Satoh M, et al. Prospective randomized phase ii trial of a single early intravesical instillation of pirarubicin (thp) in the prevention of bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma: the thp monotherapy study group trial[J]. J Clin Oncol, 2013, 31(11): 1422-1427.
[20]
O'Brien T, Ray E, Singh R, et al. Prevention of bladder tumours after nephroureterectomy for primary upper urinary tract urothelial carcinoma: a prospective, multicentre, randomised clinical trial of a single postoperative intravesical dose of mitomycin C (the ODMIT-C Trial)[J]. Eur Urol, 2011, 60(4): 703-710.
[21]
Wu WJ, Ke HL, Yang YH, et al. Should patients with primary upper urinary tract cancer receive prophylactic intravesical chemotherapy after nephroureterectomy[J].J Urol, 2010, 183(1): 56-61.
[22]
Yuan H, Mao X, Bai Y, et al. The effect of intravesical chemotherapy in the prevention of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: a meta-analysis[J]. J Chemother, 2015, 27(4): 195-200.
[23]
Dobé T, Califano G, von R, et al. Postoperative chemotherapy bladder instillation after radical nephroureterectomy: results of a european survey from the young academic urologist urothelial cancer group[J]. Eur Urol Open, 2020, 22(22): 45-50.
[24]
Michael A, Uhlman MA, Bing MT, et al. Evaluating the safety of intraoperative instillation of intravesical chemotherapy at the time of nephroureterectomy[J]. BMC Urol, 2015, 15(1): 45-51.
[25]
Nadler N, Oedorf K, Jensen J, et al. Intraoperative mitomycin c bladder installation during radical nephroureterectomy is feasible and safe[J]. Eur Urol Open Sci, 2021, 34(34): 41-46.
[26]
黄健,王建业,孔垂泽,等.中国泌尿外科和男科疾病诊断治疗指南[M]. 2019版. 北京: 科学出版社, 2019: 202.
[27]
Wu P, Zhu G, Wei D, et al. Prophylactic intravesical chemotherapy decreases bladder tumor recurrence after nephroureterectomy for primary upper tract urothelial carcinoma: A systematic review and meta-analysis[J]. J BUON, 2015, 20(5): 1229-1238.
[28]
Yuval F, Rashed G, Nirmish S, et al. Intraoperative prophylactic intravesical chemotherapy to reduce bladder recurrence following radical nephroureterectomy[J]. Urol Oncol, 2020, 38(9): 737.e11-737.e16.
[29]
Fan, B, Teng, Q, Sun, M, et al. Assessment of therapeutic benefit and option strategy on intravesical instillation for preventing bladder cancer recurrence after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma[J]. J Oncol, 2022, 1755368.
[30]
Power NE, Izawa J. Comparison of guidelines on non-muscle invasive bladder cancer (EAU, CUA, AUA, NCCN, NICE)[J]. Bladder Cancer, 2016, 2(1): 27-36.
[31]
Long X, Qi L, Zu X, et al. Prevention of recurrent bladder tumors after nephroureterectomy for primary upper urinary tract urothelial carcinoma: an individualized selection strategy based onpatient risk stratification is needed[J]. Urol Int, 2017, 98(3): 312-319.
[32]
Huang Y, Cen J, Liu Z, et al. A comparison of different prophylactic intravesical chemotherapy regimens for bladder cancer recurrence after nephroureterectomy for primary upper tract urothelial carcinomas: a retrospective 2-center study[J].Technol Cancer Res Treat, 2019, 18(1): 1-9.
[33]
Miyake M, Tatsumi Y, Matsumoto H, et al. Outcomes of subsequent non-muscleinvasive bladder cancer treated with intravesical Bacillus Calmette‐Guérin after radical nephroureterectomy for upper urinary tract urothelial carcinoma[J]. BJU Int, 2018, 121(5): 764-773.
[34]
Lu DD, Boorjian SA, Raman JD, et al. Intravesical chemotherapy use after radical nephroureterectomy: A national survey of urologic oncologists[J]. Urol Oncol, 2017, 35(3): 113.e1-e7.
[35]
Metcalfe M, Wagenheim G, Xiao L, et al. Induction and maintenance adjuvant mitomycin c topical therapy for upper tract urothelial carcinoma: tolerability and intermediate term outcomes[J]. J Endourol, 2017, 31(9): 946-953.
[36]
Yoo SH, Jeong CW, Kwak C, et al.Intravesical chemotherapy after radical nephroureterectomy for primary upper tract urothelial carcinoma:asystematic review and network meta-analysis[J]. J Clin Med, 2019, 8(7): 1059.
[37]
Miyamoto K, Ito A, Wakabayashi M, et al. A Phase III trial of a single early intravesical instillation of pirarubicin to prevent bladder recurrence after radical nephroureterectomy for upper tract urothelial carcinoma (JCOG1403, UTUC THP Phase III)[J]. Jpn J Clin Oncol, 2018, 48(1): 94-97.
[38]
吴肖冰,葛力源,戴黎阳,等.上尿路尿路上皮癌术后预防性膀胱灌注化疗的临床意义[J]. 中华泌尿外科杂志, 2017, 38(4): 286-289.
[39]
王安莲,王勋,刘赟,等. 上尿路尿路上皮癌术后膀胱内复发的危险因素及预防性膀胱灌注化疗的意义[J]. 国际泌尿系统杂志, 2019, 39(3): 457-460.
[40]
Fechner G, Pocha K, Schmidt D, et al. Reducing recurrence and costsin superficial bladder cancer: preclinical evaluation of osmotic cytolysis by distilled water vs. mitomycin[J].Int J Clin Pract, 2006, 60(10): 1178-1180.
[41]
Satoshi Y, Shinichi S, Yusuke I, et al. Intravesical irrigation might prevent bladder recurrence in patients undergoing radical nephroureterectomy for upper urinary tract urothelial carcinoma[J].Int J Urol, 2019, 26(8): 791-796.
[42]
廖国栋,俞蔚文,张琦,等. 单次与多次膀胱灌注方案对原发性上尿路尿路上皮癌术后预后的影响[J]. 中国临床药理学与治疗学, 2017, 22(4): 461-465.
[1] 施杰, 李云涛, 高海燕. 腋窝淋巴结阳性Luminal A型乳腺癌患者新辅助与辅助化疗的预后及影响因素分析[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 353-361.
[2] 王雪菲, 海琳悦, 李立方, 肖春花. Luminal A型乳腺癌的内分泌治疗与化疗[J]. 中华乳腺病杂志(电子版), 2023, 17(05): 294-300.
[3] 张华, 孙宇, 乡世健, 李樱媚, 王小群. 循环肿瘤细胞预测晚期胃肠癌患者化疗药物敏感性的研究[J]. 中华普通外科学文献(电子版), 2023, 17(06): 422-425.
[4] 张焱辉, 张蛟, 朱志贤. 留置肛管在中低位直肠癌新辅助放化疗后腹腔镜TME术中的临床研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 25-28.
[5] 杨倩, 李翠芳, 张婉秋. 原发性肝癌自发性破裂出血急诊TACE术后的近远期预后及影响因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 33-36.
[6] 李建美, 邓静娟, 杨倩. 两种术式联合治疗肝癌合并肝硬化门静脉高压的安全性及随访评价[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 41-44.
[7] 燕速. 腹腔镜低位直肠癌盆腔侧方淋巴结清扫指征与策略[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 480-484.
[8] 方钟进, 黄华生, 陈早庆, 郁兆存, 郑哲明, 谢永康, 陈仲宁, 邹演辉, 刘乾海, 陈镇宏. 负压组合式输尿管镜联合输尿管软镜与经皮肾镜治疗复杂性肾结石的比较[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 601-604.
[9] 陈美仁, 戴逸骅, 张茹, 戴英波. "蛙泳"俯卧位在经皮肾镜术中的应用[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 581-586.
[10] 龙卫兵, 刘晓冰, 易仁政, 邹德博, 蒋玉斌, 陈亮, 谢超群, 刘红叶, 粟周华, 张雄峰, 李麒麟. CT、B超预定位"三步法"经皮肾镜治疗上尿路结石[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(06): 587-592.
[11] 刘恒, 侯宇川. 膀胱癌新型灌注药物的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 445-451.
[12] 康海, 谭武宾, 周松, 毛正, 米泽振, 李铁求. 膀胱癌根治术后阴茎转移一例报告[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 523-525.
[13] 余俊豪, 麻立. 经腹全腹腔镜上尿路尿路上皮癌根治术在临床中的应用[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 529-532.
[14] 吴晨瑞, 廖锐, 贺强, 潘龙, 黄平, 曹洪祥, 赵益, 王永琛, 黄俊杰, 孙睿锐. MDT模式下肝动脉灌注化疗联合免疫靶向治疗肝细胞癌多处转移一例[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 713-716.
[15] 李斌奎. 不可切除肝内胆管细胞癌的转化治疗[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 511-516.
阅读次数
全文


摘要