The incidence and risk factors of urinary tract infection in patients with prostatic hyperplasia following invasive urodynamic investigation

doi:10.3877/cma.j.issn.1674-3253.2019.01.012

Abstract

Abstract:

Objective

To investigate the incidence and related risk factors of urinary tract infection in patients with prostatic hyperplasia following urodynamic study.

Methods

A total of 540 patients with prostatic hyperplasia, who underwent urodynamic study in our hospital from January 2012 to June 2017 were recruited in this study. Before urodynamic study, urinalysis and bacterial culture was performed. Patients with negative results were selected for urodynamic study. Between 24 h and 48 h after the examination, urinalysis and urine culture were performed again to determine the incidence of urinary tract infection. The positive urine culture imply urinary tract infection.The patients' baseline characteristics and urodynamic parameters were analyzed.

Results

Among the 540 patients, urinary infection was found in 45 cases after the examination, the incidence was 8.33%. Comorbidity with diabetes, bladder outlet obstruction, post void residual (PVR), volume of prostate (Vp), maximal flow rate (Qmax) and average flow rate (Qav) were found to be the independent risk factors for urinary tract infection following urodynamic study.The most common pathogens were Escherichia coli and Enterococcus (51%, 20%).

Conclusion

Patients with diabetes mellitus, bladder outlet obstruction, high residual urine volume, large prostate volume, low maximum urinary flow rate, low average urinary flow rate, may need to be treated with prophylactic antibiotics to prevent postoperative urinary tract infection. It may be beneficial to start a short course of the prophylactic antibiotics treatment following urodynamic study.

Key words: Urodynamic, Urinary tract infection, Risk factors

Wei Du, Zhaoying Fan, Xiaosong Song, Qiangguo Yu, Dong Li. The incidence and risk factors of urinary tract infection in patients with prostatic hyperplasia following invasive urodynamic investigation[J]. Chinese Journal of Endourology(Electronic Edition), 2019, 13(01): 49-51.

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Figures/Tables 3

References 14

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组别	例数	年龄（岁，±s ）	体质量指数（kg/m²，±s ）	尿路感染史（例）	尿路手术史（例）	糖尿病（例）
感染患者	45	65±6	24±2.5	22(48.9)	3(6.7)	17(37.8)
非感染患者	495	63±5	23.9±1.5	132(26.7)	34(6.9)	79(16)0
统计值	?	t=1.429	t=0.509	χ²=9.993	χ²=0.120	χ²=13.434
P值	?	0.153	0.613	<0.001	0.998	<0.001

组别	例数	年龄（岁，±s ）	体质量指数（kg/m²，±s ）	尿路感染史（例）	尿路手术史（例）	糖尿病（例）
感染患者	45	65±6	24±2.5	22(48.9)	3(6.7)	17(37.8)
非感染患者	495	63±5	23.9±1.5	132(26.7)	34(6.9)	79(16)0
统计值	?	t=1.429	t=0.509	χ²=9.993	χ²=0.120	χ²=13.434
P值	?	0.153	0.613	<0.001	0.998	<0.001

组别	例数	体积（ml，±s ）	最大尿流率（ml/s，±s ）	平均尿流率（ml/s，±s ）	残余尿（ml，±s ）	膀胱容量（ml，±s ）	膀胱出口梗阻[例（%）]	逼尿肌过度活动[例（%）]	膀胱感觉过敏[例（%）]
感染患者	45	71±18	08.1±2.7	3.7±1.5	51±17	364±53	023(51.1)	010(22.2)0	11(24.4)
非感染患者	495	50±13	10.9±2.4	5.2±1.4	24±12	350±68	130(26.3)	100(20.2)	85(17.2)
统计值	?	t=7.804	t=7.504	t=6.468	t=5.268	t=1.358	χ²=12.543	χ²=0.104	χ²=1.493
P值	?	<0.001	<0.001	<0.001	<0.001	0.175	<0.001	0.747	0.222

组别	例数	体积（ml，±s ）	最大尿流率（ml/s，±s ）	平均尿流率（ml/s，±s ）	残余尿（ml，±s ）	膀胱容量（ml，±s ）	膀胱出口梗阻[例（%）]	逼尿肌过度活动[例（%）]	膀胱感觉过敏[例（%）]
感染患者	45	71±18	08.1±2.7	3.7±1.5	51±17	364±53	023(51.1)	010(22.2)0	11(24.4)
非感染患者	495	50±13	10.9±2.4	5.2±1.4	24±12	350±68	130(26.3)	100(20.2)	85(17.2)
统计值	?	t=7.804	t=7.504	t=6.468	t=5.268	t=1.358	χ²=12.543	χ²=0.104	χ²=1.493
P值	?	<0.001	<0.001	<0.001	<0.001	0.175	<0.001	0.747	0.222

指标	B	Wald	P值	95%CI
尿路感染	-0.57	1.32	0.25	0.22～1.49
糖尿病	-0.15	6.39	0.01	1.03～1.31
体积	-0.15	32.23	0.00	0.82～0.91
最大尿流	-0.49	3.16	0.03	0.95～2.79
平均尿流	-0.86	2.93	0.04	0.88～6.38
残余尿	-0.02	8.12	0.00	0.96～0.99
膀胱梗阻	-4.86	22.21	0.00	17.07～97.77

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