Advanced transitional cell carcinoma (TCC) in renal pelvic and ureter was commonly observed with tumor invasion in ureter orifice or lymph node or metastasis in the lungs. Herein, 4 such cases were presented in multi-disciplinary team (MDT) model for individual treatment.

Four cases with TCC complicated with ureter orifice invasion and lymph node or lung metastasis were introduced. Of 4 cases, 3 were male, 1 was femal; the average age was 73 years and history of hemoturia was 10 months; 3 cases were observed of tumor involvement in whole length of ureter; all 4 cases were presented with ipsilateral ureter orifice invasion and retroperitoneal or pelvic lymph node invasion and one experienced lung metastasis. In accordance with MDT protocol, endoscopic radical renal-ureterectomy was performed.

All the 4 patients were successfully operated and received adjuvant therapy after operation. The median follow-up time was 33 months. The renal function of the healthy side of 4 patients was normal and no tumor recurrence was found.

In MDT model, it is novel to good prognosis after radical incision of TCC tumor mass for patients with advanced TCC.