Clinical characteristics and prognosis of primary prostate sarcoma in adults

doi:10.3877/cma.j.issn.1674-3253.2020.06.013

Abstract

Abstract:

Objective

To investigate the clinical characteristics, imaging and pathological features, treatment and prognosis of primary prostate sarcoma in adults.

Methods

A retrospective analysis was performed on the clinical data of 12 patients with primary prostate sarcoma from January 1999 to December 2019 in the First Affiliated Hospital of Sun Yat-Sen University.

Results

12 patients were diagnosed as prostate sarcoma by trans-rectal ultrasound prostate (TRUS-biopsy), pathological diagnosis revealed that 6 cases with rhabdomyosarcoma, 3 cases with leiomyosarcoma, 2 cases with undifferentiated sarcoma and 1 cases with carcinoid sarcoma. 2 patients received radical cystoprostatectomy and Bricker operation, 5 patients received radical prostatectomy, 2 patients received chemotherapy and radiotherapy, 1 patients received just chemotherapy, 1 patients just underwent prostate biopsy. And postoperative follow-up was performed.They all experienced recurrence and died as a result of disease progression except one patient who is still under follow-up. The average survival time was 15 months.

Conclusion

Prostate sarcoma is rare and highly malignant. The diagnosis is confirmed by TRUS-biopsy and MRI. Surgery remains the main treatment option, chemotherapy and radiotherapy provide therapeutic benefits.

Key words: Prostate sarcoma, Molecular pathology, Gene rearrangement, Sequencing, MDT, Prognosis

Jincheng Pan, Shuangjian Jiang, Chengqiang Mo, Yu Chen. Clinical characteristics and prognosis of primary prostate sarcoma in adults[J]. Chinese Journal of Endourology(Electronic Edition), 2020, 14(06): 456-459.

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URL: https://zhqjmnmwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3253.2020.06.013

https://zhqjmnmwkzz.cma-cmc.com.cn/EN/Y2020/V14/I06/456

Figures/Tables 2

References 11

[1]	Wang X, Liu L, Tang H, et al. Twenty-five cases of adult prostate sarcoma treated at a high-volume institution from 1989 to 2009[J]. J Urol, 2013, 82(1): 160-165.
[2]	Schildhaus H, Lokka S, Fenner W, et al. Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient-case report and review of clinicopathological features[J]. Diagn pathol, 2016, 11(1): 56.
[3]	Musser JE, Assel M, Mashni JW, et al. Adult Prostate Sarcoma: The memorial sloan kettering experience[J]. J Urol, 2014, 84(3): 624-628.
[4]	冼土增, 张俊夫, 罗飞, 等. 多参数磁共振成像联合四基因模型提高前列腺癌早期诊断效能的临床研究[J/CD]. 中华腔镜泌尿外科杂志（电子版）, 2018, 12(3): 149-153.
[5]	Alves LJ, Gameiro CD, Lopes S P, et al. Prostate leiomyosarcoma: a rare misleading tumor[J]. J Urol, 2019, 130: 13-16.
[6]	Vandoros GP, Manolidis T, Karamouzis MV, et al. Leiomyosarcoma of the prostate: case report and review of 54 previously published cases[J]. Sarcoma, 2008, 458709.
[7]	Olivas AD, Antic T. Rhabdomyosarcoma of the Adult Prostate: A Case Report With Complete Molecular Profile[J]. Int J Surg Pathol, 2020, 28(1): 92-98.
[8]	毛全宗, 李汉忠, 肖河, 等. 成人前列腺肉瘤的手术方式探讨及疗效分析[J]. 中华泌尿外科杂志, 2016, 37(1): 30-33.
[9]	Sexton W J, Lance R E, Reyes A O, et al. Adult prostate sarcoma: the m. d. anderson cancer center experience[J]. J Urol, 2001, 166(2): 521-525.
[10]	De Bari B, Stish B, Ball M W, et al. Adult prostatic sarcoma: a contemporary multicenter rare cancer network study[J]. Prostate, 2017, 77(10): 1160-1166.
[11]	Ball M W, Sundi D, Reese A C, et al. Multimodal therapy in the treatment of prostate sarcoma: the johns hopkins experience[J]. Clin Genitourin Cancer, 2015, 13(5): 435-440.

病例	年龄（年）	PSA（μg/L）	病理组织类型	手术	化疗	放疗	生存状态	生存时间（月）
1	28	3.34	横纹肌肉瘤	否	否	否	死亡	8
2	23	5.67	未分化肉瘤	前列腺切除术	是	是	死亡	11
3	64	0.72	横纹肌肉瘤	膀胱前列腺切除术	否	否	生存	13
4	35	3.02	平滑肌肉瘤	前列腺切除术	否	否	死亡	19
5	42	1.20	横纹肌肉瘤	膀胱前列腺切除术	是	否	死亡	23
6	37	2.55	未分化肉瘤	否	是	否	死亡	12
7	20	1.88	平滑肌肉瘤	前列腺切除术	是	否	死亡	25
8	62	2.73	横纹肌肉瘤	前列腺切除术	是	否	死亡	18
9	48	3.81	癌肉瘤	否	是	否	死亡	11
10	45	3.88	平滑肌肉瘤	否	是	是	死亡	13
11	66	2.99	横纹肌肉瘤	否	是	是	死亡	8
12	32	3.56	横纹肌肉瘤	前列腺切除术	是	否	死亡	19

病例	年龄（年）	PSA（μg/L）	病理组织类型	手术	化疗	放疗	生存状态	生存时间（月）
1	28	3.34	横纹肌肉瘤	否	否	否	死亡	8
2	23	5.67	未分化肉瘤	前列腺切除术	是	是	死亡	11
3	64	0.72	横纹肌肉瘤	膀胱前列腺切除术	否	否	生存	13
4	35	3.02	平滑肌肉瘤	前列腺切除术	否	否	死亡	19
5	42	1.20	横纹肌肉瘤	膀胱前列腺切除术	是	否	死亡	23
6	37	2.55	未分化肉瘤	否	是	否	死亡	12
7	20	1.88	平滑肌肉瘤	前列腺切除术	是	否	死亡	25
8	62	2.73	横纹肌肉瘤	前列腺切除术	是	否	死亡	18
9	48	3.81	癌肉瘤	否	是	否	死亡	11
10	45	3.88	平滑肌肉瘤	否	是	是	死亡	13
11	66	2.99	横纹肌肉瘤	否	是	是	死亡	8
12	32	3.56	横纹肌肉瘤	前列腺切除术	是	否	死亡	19

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