Abstract:
Objective To compare the clinical efficacy of transurethral resection of the bladder tumor(TURBT) combined with intravenous chemotherapy and radical cystectomy in the treatment of muscle invasive bladder cancer(MIBC).
Methods A retrospective analysis was made of the clinical data of 96 patients with stage T2 MIBC admitted to the urology department of our hospital from January 2011 to August 2014. According to the different treatment methods, 55 patients with TURBT combined with intravenous chemotherapy were selected as observation group and 41 patients with radical cystectomy (RC) as control group. The perioperative indexes, incidence of complications and prognosis were compared between the two groups.
Results In the observation group, the operative time was (65.3±12.5) min, the intraoperative blood loss was (68.6±11.2) ml, and the intestinal recovery time was (1.4±0.3) d. In the control group, the operative time was (172.3±27.4) min, the intraoperative blood loss was (398.3±96.3) ml, and the intestinal recovery time was (4.3±0.6) d. The operative time, intestinal function recovery time and intraoperative blood loss of the observation group were all better than those of the control group, with statistically significant differences (P<0.05). The incidence of postoperative complications in the observation group was 16.3%, significantly lower than that in the control group (52.2%). Among the long-term complications, the incidence of recurrent urinary infection in the observation group was 3.6%, significantly lower than that in the control group (26.8%), and the above differences were statistically significant (P<0.05).There was no significant difference in the incidence of hydronephrosis between the two groups (P>0.05). During the follow-up period, there was no significant difference in the recurrence rate, 1-year, 3-year and 5-year overall survival rate and tumor-specific survival rate between the two groups (P>0.05).
Conclusion The prognosis of TURBT combined with intravenous chemotherapy is similar to that of RC, and the surgical trauma is smaller and the quality of life is better after TURBT combined with intravenous chemotherapy.
Key words:
TURBT,
Radical cystectomy,
Myometrial invasive bladder cancer,
Clinical efficacy
Wei Wang, Jie Luan, Zhen Liu, Dezhu Qi, Peigen Wang. Comparative study of the efficacy of transurethral resection of the bladder tumor combined with intravenous chemotherapy and radical cystectomy for muscle invasive bladder cancer[J]. Chinese Journal of Endourology(Electronic Edition), 2021, 15(03): 198-202.