To summarize the management experiences of recurrent fever after percutaneous nephrolithotomy in patients with long-term oral glucocorticoids.

The data of one patient admitted to Guizhou Provincial People’s Hospital with recurrent fever after percutaneous nephro-lithotripsy with long-term oral glucocorticoids was retrospectively analyzed, then the relevant literature were reviewed and discussed.

The patient developed recurrent hyperthermia after percutaneous nephrolithotomy, after excluding various risk factors for refractory infection, the patient was considered to have autoimmune deficiency caused by long-term oral glucocorticoid, and was discharged after reasonable antibacterial medication treatment and immunity enhancement.

Patients with recurrent fever after percutaneous nephrolithotomy, it is important to investigate whether there are factors that cause autoimmune deficiency, then reduce immunosuppressive factors and enhance the body's active and passive immune capacity while treating with reasonable antibacterial drugs.