This paper reports a case of advanced penile cancer. The patient was a 44-year-old male who was admitted to our hospital due to "penile ulceration for 3 months and urinary leakage for over 1 month." Physical examination revealed significant swelling at the distal end of the penis, with the foreskin being non - retractable and exudate from the ulcerated foreskin opening. A mass about 4 cm×3 cm in size, with a firm texture and poor mobility, was visible in the right inguinal region. Enlarged lymph nodes were palpable in both inguinal regions. Imaging examinations suggested penile cancer with multiple lymph node metastases in the bilateral inguinal regions and beside the external iliac artery. After multidisciplinary consultation by Guangdong Urological Association, the expert group recommended completing a comprehensive assessment of the whole body, followed by neoadjuvant therapy and immunotherapy. Then, a total penectomy should be performed, along with inguinal and pelvic lymph node dissection either simultaneously or in stages. The necessity for adjuvant therapy or radiotherapy would be assessed based on the postoperative situation. The patient was informed of the recommendations. After full communication and obtaining informed consent, a partial penectomy was carried out. The postoperative pathology showed non-HPV-related squamous cell carcinoma, poorly differentiated (sarcomatoid squamous cell carcinoma). Following four cycles of adjuvant chemotherapy, the lymph node metastases were significantly relieved. Subsequently, bilateral inguinal lymph node dissection was performed. Regular follow-up examinations after the operation showed no signs of local recurrence or lymph node recurrence and metastasis. This case indicated that for advanced penile cancer, a comprehensive treatment model combining surgical treatment with chemotherapy, immunotherapy, etc., is the key to significantly improving the therapeutic effect.