The expression and significance of HIF-1&#x03B1;/VEGF in prostatic hyperplasia tissues of type 2 diabetes patients

doi:10.3877/cma.j.issn.1674-3253.2026.04.006

Abstract

Abstract:

Objective

To analyze the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients with benign prostatic hyperplasia and type 2 diabetes, and to explore the clinical significance.

Methods

The clinical data of 74 patients who underwent transurethral prostatectomy in our hospital from January 2020 to May 2024 were analyzed. According to whether they had type 2 diabetes, the patients were divided into two groups, the prostatic hyperplasia group (control group, n=37) and type 2 diabetes with prostatic hyperplasia group (observation group, n=37). The expression of HIF-1α and VEGF in prostate hyperplasia tissues of two groups of patients was detected by immunofluorescence immunohistochemical staining, and statistical analysis was performed.

Results

The expression of HIF-1α in the observation group of benign prostatic hyperplasia tissue was significantly higher than that in the control group (Z=2.046, P=0.041). The expression of VEGF in the observation group of benign prostatic hyperplasia tissue was also significantly higher than that in the control group (Z=2.496, P=0.013). The expression of VEGF was positively correlated with HIF-1α in the observation group (r=0.327, P=0.049).

Conclusion

The activation of HIF-1α/VEGF pathway may be related to benign prostatic hyperplasia in type 2 diabetes patients.

Key words: Benign prostatic hyperplasia, Diabetes, HIF-1α/VEGF, Signaling pathway

Yingli Lin, Mengli Jin, Jiandong Hu, Tinghui Yan. The expression and significance of HIF-1α/VEGF in prostatic hyperplasia tissues of type 2 diabetes patients[J]. Chinese Journal of Endourology(Electronic Edition), 2026, 20(04): 407-412.

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References 30

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组别	例数	年龄[岁，(±s)]	体质量指数[kg/m²，(±s)]	前列腺增生病程[年，(±s)]	前列腺质量[g，M(Q)]
观察组	37	71.38±6.88	24.91±2.79	9.75±4.96	76.52(63.83，90.78)
对照组	37	71.24±6.37	24.39±2.25	8.94±4.68	74.52(65.17，86.43)
统计值		t=0.088	t=0.883	t=0.719	Z=0.319
P值		0.930	0.380	0.475	0.750

组别	例数	年龄[岁，(±s)]	体质量指数[kg/m²，(±s)]	前列腺增生病程[年，(±s)]	前列腺质量[g，M(Q)]
观察组	37	71.38±6.88	24.91±2.79	9.75±4.96	76.52(63.83，90.78)
对照组	37	71.24±6.37	24.39±2.25	8.94±4.68	74.52(65.17，86.43)
统计值		t=0.088	t=0.883	t=0.719	Z=0.319
P值		0.930	0.380	0.475	0.750

组别	HIF-1α	VEGF
观察组	15（7，22）	12（6，21）
对照组	9（7，14）	8（6，11）
Z值	2.046	2.496
P值	0.041	0.013

组别	HIF-1α	VEGF
观察组	15（7，22）	12（6，21）
对照组	9（7，14）	8（6，11）
Z值	2.046	2.496
P值	0.041	0.013

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