To compare the safety and efficacy of transvesical prostatectomy(TVP)and plasma kinetic resection of prostate (PKRP) for treating big volume prostate in primary hospital.

Eighty patients with urodynamic obstruction and whose prostate volume was bigger than 80 ml were prospectively randomized and assigned to TVP group or PKRP group. Patients were assessed preoperatively and followed up at 3 and 12 months postoperatively. International prostate symptom score, quality of life score and maximum flow rate were obtained. Perioperative data and postoperative complications were also recorded.

Among 80 participants, 69 patients completed 12 months of follow-up. There were no significant differences in operation time and the weight of resecting prostate between the two groups. The PKRP group had significantly less blood loss of operation, shorter postoperative bladder washing time, shorter postoperative catheterization time and shorter hospital stay than the TVP group. There were no significant differences in International prostate symptom score, quality of life score and maximum flow rate between the two groups at 3 or 12 months of follow-up.

Both PKRP and TVP are effective alternatives for treatment of benign prostatic hyperplasia whose volume, is bigger than 80 ml, but PKRP is less wound and recover rapidly so that it worth to popularize in primary hospital.