To evaluate the efficacy of bladder perfusion with sodium hyaluronate combined with ultrashort wave irradiation in bladder region in treatment of non-bacterial cystitis.

Altogether 46 patients who were diagnosed as non-bacterial cystitis in our hospital from March 2013 to June 2016 were divided into three groups according to different treatment methods: 18 patients who accepted bladder perfusion with mixed liquid [dexamethasone + chymotrypsin + lidocaine + SWFI (Sterile Water for Injection)] were classified as Control Group; 13 patients who accepted bladder perfusion with sodium hyaluronate solution and ultra-shortwave radiation in the bladder area were classified as Experiment A Group; 15 patients who simply accepted intravesical instillation of sodium hyaluronate were classified as Experiment B Group. All the patients underwent the same course of instillation treatment (once a week for 12 times and then once every two weeks for 6 times) and accepted cystoscopy re-examinations before treatment, during 3-month treatment and after treatment. In the lesion area, the general view was adopted to take photos and the biopsy was performed for HE staining. Questionnaires were made before treatment, during 3-month treatment and after treatment respectively, to record pelvic pain+urgency / frequency symptom score (PUF score), cystoscopy, HE-stained lymphocytes for calculation of the histological score of cystitis, micturition diary for calculation of the frequency of daily micturition and maximum bladder capacity, as well as intra-treatment adverse reactions. Data changes of three groups were also observed and analyzed.

Among all the cases, 45 cases were followed up for 6 months, while, the treatment for 1 patient in Experiment B Group was discontinued due to itchy skin after two continuous perfusions. The post-treatment indexes of Experiment A Group and Experiment B Group such as the PUF score, the histological score of cystitis, the frequency of daily micturition and maximum bladder capacity had statistically significant difference in contrast with pre-treatment ones (P<0.05) and those of Control Group at the same period (P<0.05). No statistically significant difference was seen in the post-treatment indexes listed hereinabove of neither Experiment Group, but Experiment A Group was better than Experiment B Group in intra-treatment indexes, with statistically significant difference (P<0.05). No serious adverse reactions were found during the treatment.

Combination of application of bladder perfusion with sodium hyaluronate and ultrashort wave irradiation has clear effect in the treatment of non-bacterial cystitis without serious complications. In comparison with simple perfusion of sodium hyaluronate, combination therapy can improve the symptoms and inflammation in a faster manner, which provides a new train of thought and opens up a new space for comprehensive treatment of non-bacterial cystitis.