The clinical effectiveness of 1‰ concentration hypochloric acid (HClO) in percutaneous nephrolithotripsy on the prevention of postoperative systemic inflammatory response syndrome

doi:10.3877/cma.j.issn.1674-3253.2019.03.003

Abstract

Abstract:

Objective

To evaluate the effectiveness of 1‰ concentration hypochlorous acid (HClO)intraoperative irrigation on prevention of postoperative systemic inflammatory response syndrome (SIRS) during percutaneous nephrolithotripsy (PCNL).

Methods

The effects of HClO at concentration≤2.8‰ on proliferation inhibition and apoptosis induction of human renal tubular epithelial cells and normal bladder urothelial cells were detected by MTT assay and flow cytometry. One hundred and thirty-two patients with renal or upper ureteral stones treated in the Affiliated Hospital of Xuzhou Medical College from June 2016 to December 2017 suitable for one-stage percutaneous nephrolithotomy (PCNL) treatment were proactively chosen and randomly divided into trial group (treated with 1‰ HClO ) and control group (treated with NS) by random number table method. The rate of SIRS between two groups was analyzed and compared.

Results

HClO≤2.8‰ did not significantly inhibit proliferation and induce apoptosis in human renal tubular epithelial cells and normal bladder urothelial cells (P>0.05). The incidence of postoperative SIRS in the trial group (9.52%) was lower than that in the control group (28.99%).

Conclusion

Intraoperative irrigation of 1‰ HClO in PCNL is significant for prevention of postoperative SIRS and postoperative prognosis of patients. It is worth further clinical application.

Key words: PCNL, Kidney stones, Hypochlorous acid, SIRS

Jianqiang Wu, Hao Zhao, Cheng Huang, Rumin Wen, Wang Li, Jiacun Chen, Huan Cheng. The clinical effectiveness of 1‰ concentration hypochloric acid (HClO) in percutaneous nephrolithotripsy on the prevention of postoperative systemic inflammatory response syndrome[J]. Chinese Journal of Endourology(Electronic Edition), 2019, 13(03): 153-157.

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组别	例数	年龄（岁，±s）	性别（例）		BMI>24kg/m²（例）	糖尿病（例）	手术时间（min，±s）	手术通道[例（单∶多）]
组别	例数	年龄（岁，±s）	男	女	BMI>24kg/m²（例）	糖尿病（例）	手术时间（min，±s）	手术通道[例（单∶多）]
观察组	63	46±11	35	28	37	17	86±8	60∶3
对照组	69	46±11	37	32	44	22	85±8	64∶5
统计值	?	t=0.077	χ²=0.050		χ²=0.353	χ²=0.380	t=0.848	-
P值	?	0.939	0.824		0.553	0.538	0.398	0.720
组别	例数	结石大（cm³，±s）	术中出血（ml，±s）	尿培养[例（阳∶阴）]	抗生素[例（是∶否）]	结石细菌培养[例（阳∶阴）]
观察组	63	3.6±0.7	85±10	20∶43	42∶21	31∶32
对照组	69	3.5±0.9	86±12	22∶47	43∶26	35∶34
统计值	?	t=5.040	χ²=0.767	χ²=0.000	χ²=0.272	χ²=0.030
P值	?	0.615	0.444	0.986	0.602	0.862

组别	例数	年龄（岁，±s）	性别（例）		BMI>24kg/m²（例）	糖尿病（例）	手术时间（min，±s）	手术通道[例（单∶多）]
组别	例数	年龄（岁，±s）	男	女	BMI>24kg/m²（例）	糖尿病（例）	手术时间（min，±s）	手术通道[例（单∶多）]
观察组	63	46±11	35	28	37	17	86±8	60∶3
对照组	69	46±11	37	32	44	22	85±8	64∶5
统计值	?	t=0.077	χ²=0.050		χ²=0.353	χ²=0.380	t=0.848	-
P值	?	0.939	0.824		0.553	0.538	0.398	0.720
组别	例数	结石大（cm³，±s）	术中出血（ml，±s）	尿培养[例（阳∶阴）]	抗生素[例（是∶否）]	结石细菌培养[例（阳∶阴）]
观察组	63	3.6±0.7	85±10	20∶43	42∶21	31∶32
对照组	69	3.5±0.9	86±12	22∶47	43∶26	35∶34
统计值	?	t=5.040	χ²=0.767	χ²=0.000	χ²=0.272	χ²=0.030
P值	?	0.615	0.444	0.986	0.602	0.862

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