Abstract:
Objective To compare the clinical effect of transurethral laser shovel type vapor-resection-enucleation of the prostate (LS-VREP) and transurethral resection of prostate (TURP) for benign prostatic hyperplasia (BPH), and to evaluate immune function of LS-VREP in treatment of BPH.
Methods A retrospective analysis of 86 patients with BPH from January 2017 to March 2019 in our hospital were included, they were divided into two groups, 43 cases were treated with LS-VREP, other 43 cases were treated with TURP. Comparisons between the two groups were made with respect to duration of operative time, intraoperative blood loss, postoperative irrigation time, postoperative indwelling catheterization, hospital stay and complication rate. Moreover, blood indicators changes of immune function (IgG, IgA, lgM, CD8+CD28-, CD8+CD28+) in patients with BPH before surgery and after surgery, indicators changes of IPSS, QOL, Qmax and RUV in the preoperative, postoperative 3 months and postoperative 6months between two groups were detected.
Results All the 86 patients underwent sugery successfully. The mean operative time, blood loss, postoperative irrigation time, indwelling catheterization, postoperative hospital stay and complication rate were (47.4±18.3) min, (62.9±33.4) ml, (18.3±5.1) hours, (32.5±10.6) hours, (4.3±1.6) days, 4.8% in group LS-VREP and (49.6±21.1) min, (106.5±57.2) ml, (45.7±10.9) hours, (53.8±13.4) hours, (5.9±2.4) days, 12.8% in group TURP. Besides, LS-VREP reduce blood loss and complications, shorten postoperative irrigation time, indwelling catheterization and hospital stay(P<0.05). After surgery, the levels of CD8+CD28- in group LS-VREP were significantly lower than in group TURP (P<0.05), and the levels of IgG, IgA, CD8+CD28+ in group LS-VREP were significantly higher than in control group (P<0.05). But there were no significant difference between the two groups in levels of lgM and CD8+ (P>0.05). Average postoperative follow-up was 11 months (range 6-18) in 82 patients, and no patient had long term complication.
Conclusions In comparison with TURP, LS-VREP demonstrates safety and controllable, shorter operative time, less blood loss, less complications, faster postoperative recovery, better protects immune function. Thus, it is worthily recommended in the clinical application.
Key words:
Benign prostatic hyperplasia(BPH),
Greenlight Laser,
Resection and enucleation of prostate,
Immunoprotein
Bingwei Wang, Guosheng Yang, Zhenwei Wang, Xiaofu Qiu, Bote Chen. Effects of transurethral laser shovel type vapor-resection-enucleation of the prostate on the immune function in patients with benign prostatic hyperplasia[J]. Chinese Journal of Endourology(Electronic Edition), 2020, 14(01): 21-25.