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Chinese Journal of Endourology(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (05): 514-519. doi: 10.3877/cma.j.issn.1674-3253.2024.05.016

• Review • Previous Articles    

The application value of prostate specific membrane antigen PET/CT in the diagnosis and treatment of renal cell carcinoma

Wenxin Xie1, Le Ma2, Ye Liu2, Xiaoming Cao3, Wanchun Zhang2,()   

  1. 1. School of Medical Imaging, Shanxi Medical University, TaiYuan 030001, China
    2. Department of Nuclear Medicine, Third Hospital of Shanxi Medical University, TaiYuan 030002, China
    3. Department of Urology, First Hospital of Shanxi Medical University, TaiYuan 030001, China
  • Received:2023-02-13 Online:2024-10-01 Published:2024-09-19
  • Contact: Wanchun Zhang

Abstract:

Renal cell carcinoma (RCC) is one of the common tumors in the urinary system, and its incidence is increasing year by year in China. Accurate diagnosis and staging are of great significance for treatment decision-making.Traditional imaging (MRI, CT etc.) is of limited value in the diagnosis of lymph node and distant metastasis of renal cell carcinoma. A number of studies have shown that prostate specific membrane antigen (PSMA) is not only highly expressed in prostate cancer cells, but also expressed in neovascularization endothelial cells of renal cell carcinoma. The application of PSMA PET/CT in renal cell carcinoma is increasing gradually, and it is of great value in the initial diagnosis, clinical stage, follow-up after treatment and curative effect evaluation of renal cell carcinoma, especially in the detection of lymph node metastasis and distant metastasis.

Key words: Renal cell carcinoma, Prostate specific membrane antigen (PSMA), Tumor marker, Radionuclide, Targeted drug, Positron-emission tomography (PET), Computed tomography, X-ray

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