Abstract:

Objective

To investigate the clinicopathologic features，diagnosis，differential diagnosis，treatment and prognosis of dedifferentiated liposarcoma of spermatic cord.

Methods

The clinical data of two patients with dedifferentiated liposarcoma of spermatic cord diagnosed in the First Affiliated Hospital of Zhengzhou Universitywere retrospectively analyzed and the related literature was reviewed.

Results

Both patients presented with right groin masses. Case 1 underwent excision of groin lesion and radical excision of right testicle. No recurrence was observed during 6 months'follow-up. Case 2 was admitted to a local health center for tumor biopsy，but no further treatment was given after pathological diagnosis in our hospital. At present，one year follow-up has been conducted and local progress has been found.

Conclusions

Dedifferentiated liposarcoma of spermatic cord is rare and often presents as painless mass in one groin or abnormal enlargement of the scrotum on one side. Detailed preoperative physical examination and imaging examination are necessary and need to be combined with histopathology，immunohistochemistry and genetic testing to confirm the diagnosis. Surgical resection is the preferred treatment，which can be supplemented with chemoradiotherapy and molecular targeted therapy if necessary. Close follow-up should be conducted after radical resection.

Key words: Dedifferentiated liposarcoma, Inguinal mass, Immunohistochemistry