Clinical value of bladder neck resection and injection of triamcinolone acetonide combined with methylprednisolone in the treatment of bladder neck contracture

doi:10.3877/cma.j.issn.1674-3253.2025.01.011

Abstract

Abstract:

Objective

To investigate the clinical efficacy of bladder neck electrocautery and injection of Triamcinolone Acetonide combined with Methylprednisolone tablets in the treatment of bladder neck contracture.

Methods

A total of 71 patients with bladder neck contracture admitted to our hospital from January 2019 to January 2022 were included as the research subjects. Patients were divided into two groups according to the time point of bladder neck injection of Triamcinolone Acetonide combined with Methylprednisolone tablets conducted in January 2020. The control group of 35 patients only received transurethral bladder neck resection， while the observation group of 36 patients received additional treatment with injection of Triamcinolone Acetonide combined with oral Methylprednisolone tablets on the basis of the control group. The maximum and average urine flow rates of the patients were observed. The International Prostate Symptom Score Scale （IPSS） was used to evaluate the symptoms of two groups of patients before and after surgery. The Quality of Life Rating Scale （QOL） was used to evaluate the quality of life of two groups of patients before and after surgery. Follow up with patients for 12 months to observe the recurrence status of both groups of patients.

Results

There was no statistically significant difference in the maximum and average urinary flow rates between the two groups before surgery （P＞0.05）. After surgery， the maximum and average urinary flow rates in the observation group were higher than those in the control group， and the difference was statistically significant （P＜0.05）. There was no statistically significant difference in IPSS and QOL scores between the two groups before surgery （P＞0.05）； After surgery， the IPSS and QOL scores of the observation group were lower than those of the control group， and the difference was statistically significant （P＜0.05）. After a 12-month follow-up， the recurrence rate in the observation group was significantly lower at 5.56% compared to the control group at 17.14%， with a statistically significant difference （P＜0.05）.

Conclusions

Bladder neck resection and injection of Triamcinolone Acetonide combined with Methylprednisolone tablets can effectively improve the clinical symptoms and quality of life of patients with bladder neck contracture， and the postoperative recurrence rate is low， which is worthy of clinical application and promotion.

Key words: Resection of bladder neck, Triamcinolone acetonide, Methylprednisolone, Glucocort icoid, Bladder neck contracture

Wenli He, Haidong Wen, Hui Liu, Wenjun Lin, Senfu Wang, Jiagen Wu. Clinical value of bladder neck resection and injection of triamcinolone acetonide combined with methylprednisolone in the treatment of bladder neck contracture[J]. Chinese Journal of Endourology(Electronic Edition), 2025, 19(01): 58-62.

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组别	例数	年龄（岁）	体质量指数（kg/m²）	最大尿流率（ml/s）	平均尿流率（ml/s）	IPSS评分	QOL评分
对照组	35	59±5	22.6±1.3	7.5±1.0	0.85±0.21	24±5	5.5±1.2
观察组	36	59±5	22.7±1.4	7.5±0.9	0.86±0.23	24±5	5.5±1.2
t值		0.376	0.251	0.136	0.191	0.083	0.176
P值		0.708	0.802	0.892	0.849	0.849	0.861

组别	例数	年龄（岁）	体质量指数（kg/m²）	最大尿流率（ml/s）	平均尿流率（ml/s）	IPSS评分	QOL评分
对照组	35	59±5	22.6±1.3	7.5±1.0	0.85±0.21	24±5	5.5±1.2
观察组	36	59±5	22.7±1.4	7.5±0.9	0.86±0.23	24±5	5.5±1.2
t值		0.376	0.251	0.136	0.191	0.083	0.176
P值		0.708	0.802	0.892	0.849	0.849	0.861

组别	例数	最大尿流率（ml/s）	平均尿流率（ml/s）	IPSS评分	QOL评分
对照组	35	14.4±2.9	10.3±2.7	17±4	3.3±0.6
观察组	36	17.2±3.3	12.5±3.0	13±4	2.2±0.5
t值		3.731	3.311	4.947	8.497
P值		＜0.001	＜0.001	＜0.001	＜0.001

组别	例数	最大尿流率（ml/s）	平均尿流率（ml/s）	IPSS评分	QOL评分
对照组	35	14.4±2.9	10.3±2.7	17±4	3.3±0.6
观察组	36	17.2±3.3	12.5±3.0	13±4	2.2±0.5
t值		3.731	3.311	4.947	8.497
P值		＜0.001	＜0.001	＜0.001	＜0.001

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