To compare the clinical efficacy and safety of Shurui single-port robotic system (Shanghai Shurui Medical Technology Co., Ltd., China) versus Mindray laparoscopic system (China) in nephron-sparing partial nephrectomy.

From February to August 2022, 20 patients undergoing nephron-sparing partial nephrectomy at the First Affiliated Hospital of Zhejiang University School of Medicine, were randomly assigned to the Shurui single-port robotic group (n=10) or the Mindray laparoscopic control group (n=10). Demographic data (age, BMI, R.E.N.A.L. score, surgical approach, gender, hypertension, diabetes, cardiovascular and cerebrovascular diseases) and perioperative outcomes (operative time, blood loss, warm ischemia time, hospital stay, postoperative pathology, preoperative and postoperative creatinine levels, and visual analogue scale pain scores) were collected. Statistical analysis was performed using Chi-square test, Fisher’s exact test, t-test, and Mann-Whitney U test.

There were no statistically significant differences between the two groups of patients in terms of age, BMI, gender distribution, R.E.N.A.L. score, preoperative creatinine level, hypertension, diabetes, cardiovascular and cerebrovascular diseases (P>0.05). The robotic group had longer operative time [198(83-264)] min vs 143(83-245) min, P=0.044] but lower blood loss [(15(2-50) mL vs 50 (10-200) mL, P=0.005]. Postoperative creatinine levels differed significantly only on postoperative day 1 [(74.0±19.6) μmol/L vs (94.1±23.5) μmol/L, P=0.030]. No statistically significant differences were observed between the two groups in terms of warm ischemia time during surgery, blood creatinine levels before discharge and one month after surgery, VAS scores at different time points after surgery, length of hospital stay, and the incidence of postoperative complications (P>0.05).

Shurui single-port robotic surgery demonstrated superior outcomes in reducing intraoperative blood loss and minimizing short-term renal function impairment compared to Mindray laparoscopy, with comparable safety profiles between the two approaches.