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中华腔镜泌尿外科杂志(电子版) ›› 2021, Vol. 15 ›› Issue (06) : 478 -483. doi: 10.3877/cma.j.issn.1674-3253.2021.06.007

临床研究

前列腺健康指数及f/tPSA对于PSA"灰区"前列腺癌诊断价值比较的Meta分析
贾伟1, 吴波1, 陈骞1, 张旭辉1, 王东文2,()   
  1. 1. 030001 太原,山西医科大学第一医院
    2. 518116 深圳,国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院泌尿外科
  • 收稿日期:2020-06-09 出版日期:2021-12-01
  • 通信作者: 王东文
  • 基金资助:
    山西省重点研发计划(社会发展领域)(201803D31110); 山西医科大学第一医院创新团队基金(YT1604); 山西省"1331工程"重点创新团队建设计划资助(1331KIRT)

Prostate health index versus free/total PSA for prostate cancer detection in patients with PSA levels in "gray area" : a systematic analysis

Wei Jia1, Bo Wu1, Qian Chen1, Xuhui Zhang1, Dongwen Wang2,()   

  1. 1. Department of Urology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
    2. Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China
  • Received:2020-06-09 Published:2021-12-01
  • Corresponding author: Dongwen Wang
引用本文:

贾伟, 吴波, 陈骞, 张旭辉, 王东文. 前列腺健康指数及f/tPSA对于PSA"灰区"前列腺癌诊断价值比较的Meta分析[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2021, 15(06): 478-483.

Wei Jia, Bo Wu, Qian Chen, Xuhui Zhang, Dongwen Wang. Prostate health index versus free/total PSA for prostate cancer detection in patients with PSA levels in "gray area" : a systematic analysis[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2021, 15(06): 478-483.

目的

系统评价前列腺健康指数(PHI)及游离/总前列腺特异性抗原(f/tPSA)对于PSA="灰区"(2~10 ng/ml)前列腺癌诊断价值的比较。

方法

通过检索Pubmed、Cochrane图书馆、Embase、中国学术期刊全文数据库、维普期刊全文数据库5个数据库,收集报告PHI、f/tPSA在PSA"灰区"前列腺癌诊断价值的文献。使用MetaDisc 1.4软件、STATA 11.0进行统计分析。

结果

共12篇文献,4 639例研究对象纳入Meta分析。穿刺诊断前列腺癌患者1 703例,穿刺阴性2 936人。PHI、f/tPSA合并敏感性分别为0.87(95%CI:0.85~0.89)、0.86(95%CI:0.84~0.87);合并特异性分别为0.42(95%CI:0.40~0.44),0.24(95%CI:0.22~0.25);ROC曲线下面积PHI:0.803,f/tPSA=0.644(P<0.001)。

结论

PHI较%fPSA在PSA"灰区"前列腺癌诊断中存在明显优势。

Objective

To investigate the value of prostate health index and free/total PSA(f/tPSA) of prostate cancer detection in patients with PSA levels between 2-10 ng/ml "gray area" .

Methods

Relevant articles in 5 online databases Pubmed, Embase, Cochrane library, CNKI, VIP were enrolled. Systematic analysis was performed by MetaDisc 1.4, STATA 11.0.

Results

12 articles and 4 639 patients were included in present analysis. As a result, a total of 1 703 patients was confirmed prostate cancer, number of patients with negative prostate biopsies was 2 936. The pooled sensitivity of PHI and f/tPSA were 0.87(95%CI:0.85-0.89) vs 0.86(95%CI:0.84-0.87), respectively, the pooled specificity of PHI and %fPSA were 0.42 (95%CI:0.40-0.44) vs 0.24(95%CI:0.22-0.25). The ROC of PHI and f/tPSA were 0.803 vs 0.644 (P<0.001).

Conclusion

PHI has a obvious advantage over the f/tPSA for prostate cancer detection in patients with PSA levels of "gray area" .

表1 纳入PHI和PSA诊断PCa文献的基本特征及质量评价
表2 PHI值诊断前列腺癌四格表
表3 f/tPSA诊断前列腺癌四格表
表4 PHI对于临床有意义前列腺癌诊断表现
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