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中华腔镜泌尿外科杂志(电子版) ›› 2022, Vol. 16 ›› Issue (05) : 476 -480. doi: 10.3877/cma.j.issn.1674-3253.2022.05.223

综述

预测前列腺癌淋巴结转移的研究进展
黄广义1, 陈征1, 秦晓平1, 卓育敏1,()   
  1. 1. 510630 广州,暨南大学附属第一医院,泌尿外科
  • 收稿日期:2021-09-26 出版日期:2022-10-01
  • 通信作者: 卓育敏
  • 基金资助:
    国家自然科学基金青年项目(81902615); 暨南大学附属第一医院博士后科研启动项目(809011); 广东省青年优秀人才国际培养计划博士后项目(2019); 领航专科建设专项-暨南大学附属第一医院(711006); 广东省科技计划项目(2020A1414010348)

Progress in predicting lymph node metastasis of prostate cancer

Guangyi Huang1, Zheng Chen1, Xiaoping Qin1   

  • Received:2021-09-26 Published:2022-10-01
引用本文:

黄广义, 陈征, 秦晓平, 卓育敏. 预测前列腺癌淋巴结转移的研究进展[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2022, 16(05): 476-480.

Guangyi Huang, Zheng Chen, Xiaoping Qin. Progress in predicting lymph node metastasis of prostate cancer[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2022, 16(05): 476-480.

前列腺癌(prostate cancer,PCa)是欧美地区男性发病率及死亡率均排第二位的恶性肿瘤[1]。近年来我国PCa发病率及死亡率呈逐年增长趋势[2]。研究发现PCa转移是导致患者预后较差的重要因素[3]。众所周知,转移性PCa中以淋巴结转移最为常见。盆腔淋巴结清扫(pelvic lymph node dissection,PLND)是诊断PCa淋巴结转移的"金标准",但目前PLND的适应证、范围和患者获益程度仍存在较大争议[4]。术前明确诊断PCa淋巴结转移有助于患者准确地分期及选择最佳的治疗方案。如何在前列腺癌根治术(radical prostatectomy,RP)前准确判断是否有淋巴结转移及转移范围是临床工作中的重点和难点。前列腺特异性抗原(prostate specific antigen,PSA)、Gleason评分、临床分期、前列腺穿刺阳性针数及其百分比、前列腺特异性抗原密度(PSA density,PSAD)、前列腺健康指数(prostate health index,PHI)、体质量指数(body mass index,BMI)、多参数磁共振成像(multiparametric magnetic resonance Imaging,mpMRI)、前列腺影像和数据系统(prostate imaging reporting and data system,PI-RADS)评分、前列腺特异性膜抗原正电子发射断层扫描成像(prostate-specific membrane antigen positron-emission tomography,PSMA PET-CT)等临床指标;MSKCC、Briganti 2012、Partin 2016、Yale、Briganti 2017和Briganti 2019等列线图模型;17-gene Oncotype DX前列腺基因组评分(genomic prostate score,GPS)、塌陷反应调节蛋白4(collapsin response mediator proteins,CRMP4)甲基化、99mTc硫胶体、光学示踪剂如吲哚菁绿(indocyanine green,ICG)、混合示踪剂等新技术均在预测PCa淋巴结转移中有相关报道。本研究系统总结了术前预测PCa淋巴结转移的各种参数及其进展。

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