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中华腔镜泌尿外科杂志(电子版) ›› 2023, Vol. 17 ›› Issue (02) : 191 -195. doi: 10.3877/cma.j.issn.1674-3253.2023.02.020

综述

前列腺癌患者骨保护现状及临床用药进展
倪鑫淼1, 王磊1, 王潇1, 陈志远1, 翁小东1,(), 刘修恒1,()   
  1. 1. 430060 武汉大学人民医院泌尿外科
  • 收稿日期:2021-12-06 出版日期:2023-04-01
  • 通信作者: 翁小东, 刘修恒
  • 基金资助:
    国家自然科学基金(NO.81972408)

Current status of bone protection in patients with prostate cancer and progress in clinical medication

Xinmiao Ni1, Lei Wang1, Xiao Wang1   

  • Received:2021-12-06 Published:2023-04-01
引用本文:

倪鑫淼, 王磊, 王潇, 陈志远, 翁小东, 刘修恒. 前列腺癌患者骨保护现状及临床用药进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(02): 191-195.

Xinmiao Ni, Lei Wang, Xiao Wang. Current status of bone protection in patients with prostate cancer and progress in clinical medication[J]. Chinese Journal of Endourology(Electronic Edition), 2023, 17(02): 191-195.

前列腺癌是世界上男性发病率第二位的恶性肿瘤,死亡率居男性癌症第五位,在欧美发达国家其发病率居首位[1]。当前我国前列腺癌发病率仍处于较低水平,但近年来随着社会经济的发展,预期寿命的提高,生活方式的转变以及医疗卫生水平的改善,我国前列腺癌的发病率正逐步升高,严重威胁着我国男性的生命安全[2]。在我国就诊的前列腺癌患者多处于中晚期,而骨骼是晚期患者最常见的转移部位,出现转移灶后可能会引起病理性骨折及脊髓压迫等症状,广泛骨转移患者容易出现疲劳、消瘦、贫血等症状,严重者甚至出现全身器官功能衰竭[3]。因此如何在治疗原发灶的同时缓解此类患者骨转移导致的症状,预防和减少骨相关事件(skeletal related events,SREs)的发生十分重要。为进一步规范和指导对前列腺癌骨转移患者的治疗,我国发布了《前列腺癌骨转移临床诊疗专家共识(2021)版》[3]。该共识对治疗前列腺癌骨转移进行了较为全面总结,治疗方式包括药物治疗、镇痛治疗、外照射放疗、核素治疗、骨外科治疗、微创介入治疗。其中药物治疗又包括药物去势治疗、新型内分泌治疗、化疗、靶向治疗以及双膦酸盐和地诺单抗等治疗。本文将就前列腺癌患者骨保护的必要性、骨况评估、各国指南中的骨保护策略及临床常用药物双膦酸盐、地诺单抗等方面的研究进展进行综述。

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