To explore the clinicopathological features, diagnosis and treatment of paraganglioma of urinary bladder (PUB).

The clinical data, pathological diagnosis and follow-up results of 2 cases with paraganglioma of urinary bladder in our hospital were analyzed retrospectively, and related literatures were also reviewed.

Case 1 was nonfunctional neoplasm without any symptoms. CT scan showed a solitary bladder nodule and was significantly enhanced. The patient underwent transurethral resection of the bladder tumor (TURBT). Case 2 was functional neoplasm with symptoms of headache, palpitation, and paroxysmal hypertension after urination, MRI showed a solitary bladder nodule with heterogeneous enhancement. After sufficient preparation including volume expansion and stability of blood pressure, the patient underwent laparoscopic partial cystectomy and the symptoms disappeared after surgery. There was no tumor recurrence or metastasis through the 9 to 12 months follow-up.

PUB is a rare tumor in clinical and can be classified as functional or nonfunctional tumors. Fully preparations should be made to prevent complications such as hypertensive crisis during operation. TURBT and laparoscopic partial cystectomy are effective treatment methods and regular follow-up after surgery is necessary.