The application of drosophila model in the research of kidney stones

doi:10.3877/cma.j.issn.1674-3253.2024.03.003

Abstract

Abstract:

Kidney stone is a key aspect of research in Urology. Currently, animal models for kidney stone research predominantly employ mammals such as mice, rats, and pigs due to their technical maturity and anatomical resemblance to humans, facilitating a faithful emulation of the human stone formation process. However, mammalian models are plagued by drawbacks such as long breeding cycles, high costs, cumbersome ethical reviews, and the complexity of physiological and genetic mechanisms. Consequently, the quest for a simpler, more economical, and feasible animal model holds significant importance for kidney stone research. Drosophila model stands out as one of the commonly utilized animal models in the field of biomedicine, which has the advantages of lower costs, shorter experimental periods, ease of observation, and strong genetic manipulability. Recently, many studies used drosophila kidney stone model in kidney stone researches, yielding promising results and underscoring the broad application prospects of drosophila kidney stone model.

Key words: Drosophila, Kidney stone, Animal model, Malpighian tubule

Ruizheng Tang, Shujue Li, Wenqi Wu. The application of drosophila model in the research of kidney stones[J]. Chinese Journal of Endourology(Electronic Edition), 2024, 18(03): 214-218.

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