To report the effect of the clinical treatment of the renal angiomyolipoma with inferior vena cava tumor thrombus through Robot-assisted laparoscopic radical nephrectomy, then review the clinical progress in diagnosis and treatment of renal angiomyolipoma with inferior vena cava tumor.

The clinical data of the patients who were treated in the First Affiliated Hospital of AnHui Medical University from March 2021 to October 2021 was analyzed and a summary with relevant literature was made.

One case was a 39 year old male and the other case was a 57 year old female, both patients’ tumors were on the right side. The size of the tumor of the male patient was 15.0 cm×10.0 cm×9.0 cm with Mayo grade Ⅱ inferior vena cava tumor thrombus. The size of the tumor of the other patient was 6.0 cm×4.8 cm×4.5cm with Mayo grade Ⅱ inferior vena cava tumor thrombus. Both of 2 cases underwent robot-assisted laparoscopic radical nephrectomy and inferior vena cava tumor thrombectomy. The operation was successful in the group without conversion to laparotomy and no complications occured during the perioperative period. Postoperative pathology proved renal angiomyolipoma with inferior vena cava thrombus. After 12 months and 3 months of follow-up, both of patients did not have relapse and transfer.

The case of renal angiomyolipoma with inferior vena cava tumor thrombus is rare in clinic which is in great need of surgical treatment, and the postoperative prognosis is normally positive. The cases we reported prove the feasibility of robot-assisted laparoscopic radical nephrectomy and inferior vena cava tumor thrombectomy in treating renal angiomyolipoma with Mayo grade Ⅱ inferior vena cava tumor thrombus.