A pilot study on urinary PCA3 combined with multiparametric MRI for the diagnosis of prostate cancer

doi:10.3877/cma.j.issn.1674-3253.2021.06.003

Abstract

Abstract:

Objective

To investigate the diagnostic value of urinary prostate cancer gene 3 (PCA3) combined with multiparametric MRI (mpMRI) in prostate cancer.

Methods

RT-PCR was used to detect the expression level of urinary PCA3 of 40 patients with prostate cancer and 28 patients with benign prostatic hyperplasia. The receiver operating characteristic (ROC) curves was constructed to analyze the sensitivity and specificity of urinary PCA3, mpMRI and the combination of them for the diagnosis of prostate cancer.

Results

The expression level of urinary PCA3 in benign prostatic hyperplasia was lower than that in prostate cancer [(2.26±0.95) copies/ml vs (6.25±1.21) copies/ml, P<0.001]. The area under ROC for PCA3, mpMRI, and the combination were 0.693 (95%CI: 0.569-0.799), 0.720 (95%CI: 0.598-0.822), and 0.830 (95%CI: 0.719-0.910), respectively.

Conclusions

The determination of urinary PCA3 combined with mpMRI was valuable biomarker for the diagnosis of prostate cancer.

Key words: Prostate cancer, Diagnosis, prostate cancer gene 3, multiparametric MRI

Ke Zhang, Wei Jiang, Zhuojun Li, Weibin Mao, Yue Zhang, Zhan'ao Meng. A pilot study on urinary PCA3 combined with multiparametric MRI for the diagnosis of prostate cancer[J]. Chinese Journal of Endourology(Electronic Edition), 2021, 15(06): 463-466.

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URL: https://zhqjmnmwkzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3253.2021.06.003

https://zhqjmnmwkzz.cma-cmc.com.cn/EN/Y2021/V15/I06/463

Figures/Tables 3

References 12

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组别	例数	年龄[岁，(±s)]	PCA3[分，(±s)]	mpMRI PI-RADS V2评分(例)			Gleason评分(例)		临床病理分期(例)
组别	例数	年龄[岁，(±s)]	PCA3[分，(±s)]	1~2	3	4~5	< 8	≥8	T1~T2	T3~T4
前列腺增生	28	69±10	38.0±16.0	17	7	04	-	-	-	-
前列腺癌	40	65±11	26.6±15.3	10	8	22	16	24	18	22
统计值		t=1.7	t=4.165	χ²=1.8			-		-
P值		0.12	<0.001	0.38			-		-

组别	例数	年龄[岁，(±s)]	PCA3[分，(±s)]	mpMRI PI-RADS V2评分(例)			Gleason评分(例)		临床病理分期(例)
组别	例数	年龄[岁，(±s)]	PCA3[分，(±s)]	1~2	3	4~5	< 8	≥8	T1~T2	T3~T4
前列腺增生	28	69±10	38.0±16.0	17	7	04	-	-	-	-
前列腺癌	40	65±11	26.6±15.3	10	8	22	16	24	18	22
统计值		t=1.7	t=4.165	χ²=1.8			-		-
P值		0.12	<0.001	0.38			-		-

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