Effect of endoluminal lignocaine irrigation on renal pelvic pressure in a porcine model of intrapelvic perfusion

doi:10.3877/cma.j.issn.1674-3253.2017.02.013

Abstract

Abstract:

Objective

To investigate the effects on the pressure-flow relation of renal pelvic pressure (RPP) with intraluminal administration of 1% lignocaine in pigs.

Methods

The animal models of intrapelvic perfusion in pigs were constructed. This experiment was randomized to two groups. Baseline: A 5 minutes period for baseline RPP measurement. Period 1: A 5 minutes period of irrigation using saline in both groups. Period 2: A 5 minutes period of irrigation with randomization for irrigating 1% lignocaine (group A) or saline (group B). Then after perfusion was done on the other side as a control in each pig. The Irrigation rate period 1 and 2 was standardized to 8 ml/min. Period 3: A 15 minutes period of irrigation using saline in both groups. During the first 5 minutes, the irrigation rate was 8 ml/min. And then the irrigation rate was changed to 16 ml/min in the second 5 minutes. In the third 5 minutes, the irrigation rate was 24 ml/min. The renal pelvic pressure, heart rate and respiratory rate were recorded.

Result

The mean baseline pelvic pressures in A and B group were (12±4) and (13±6) cmH₂O (P>0.05). The mean pelvic pressures in period 1 and period 2 were (51±12) and (54±16) cmH₂O, (47±9) and (52±15) cmH₂O (P>0.05). The mean pelvic pressures in period 3 at the irrigation rate of 8 mL/min, 16 ml/min and 24 ml/min were (43±10) and (50±17) cmH₂O (P>0.05), (49±15) and (61±17) cmH₂O (P<0.05), (54±16) and (65±14) cmH₂O (P<0.05), respectively. The mean heart rate and respiratory rate did not change significantly.

Conclusion

We conclude that 1% lidocaine can decrease pressure-flow relation.

Key words: Lignocaine, Pelvic pressure, Pig

Maoyin Li, Wenwen Zhong, Dejuan Wang, Wentao Huang, Cheng Hu, Ke Li, Jianguang Qiu. Effect of endoluminal lignocaine irrigation on renal pelvic pressure in a porcine model of intrapelvic perfusion[J]. Chinese Journal of Endourology(Electronic Edition), 2017, 11(02): 129-133.

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References 19

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组别	阶段1		阶段2		阶段3
组别	呼吸频率	心率	呼吸频率	心率	呼吸频率	心率
实验组	17.2±1.9	75.6±1.1	24.0±2.7	85.4±2.1	27.4±1.1	86.0±1.2
对照组	17.0±1.6	75.4±1.5	23.6±2.5	84.8±1.4	27.8±1.3	84.6±2.1
t值	0.206	0.173	0.232	0.885	-0.492	1.055
P值	0.847	0.871	0.828	0.426	0.648	0.351

组别	阶段1		阶段2		阶段3
组别	呼吸频率	心率	呼吸频率	心率	呼吸频率	心率
实验组	17.2±1.9	75.6±1.1	24.0±2.7	85.4±2.1	27.4±1.1	86.0±1.2
对照组	17.0±1.6	75.4±1.5	23.6±2.5	84.8±1.4	27.8±1.3	84.6±2.1
t值	0.206	0.173	0.232	0.885	-0.492	1.055
P值	0.847	0.871	0.828	0.426	0.648	0.351

组别	阶段1		阶段2		阶段3
组别	0ml/min	8 ml/min	8 ml/min	8 ml/min	16 ml/min	24ml/min
实验组	12.3±3.9	50.8±11.5	47.4±9.2	43.0±9.8	49.4±14.6	54.0±16.1
对照组	12.6±5.6	53.5±16.1	52.2±15.1	49.7±16.8	61.0±17.3	65.1±14.1
t值	-0.251	-0.731	-1.132	-1.158	-2.790	-3.867
P值	0.814	0.505	0.321	0.311	0.049	0.018

组别	阶段1		阶段2		阶段3
组别	0ml/min	8 ml/min	8 ml/min	8 ml/min	16 ml/min	24ml/min
实验组	12.3±3.9	50.8±11.5	47.4±9.2	43.0±9.8	49.4±14.6	54.0±16.1
对照组	12.6±5.6	53.5±16.1	52.2±15.1	49.7±16.8	61.0±17.3	65.1±14.1
t值	-0.251	-0.731	-1.132	-1.158	-2.790	-3.867
P值	0.814	0.505	0.321	0.311	0.049	0.018

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