To investigate the relationship between serum fibrinogen (FIB), D-dimer and alkaline phosphatase (ALP) and bone metastasis of prostate cancer (PCa), so as to provide reference for clinical diagnosis of PCa bone metastasis.

The clinical data of 98 PCa patients from April 2020 to September 2021 were retrospectively collected, including plasma FIB, D-dimer, ALP, pathological Gleason score, cT, lymph node metastasis, distant metastasis, and bone metastasis. The relationship between the above indexes and PCa bone metastasis were analyzed.

Taking bone metastases as the research object, the receiver operator characteristic (ROC) curve results showed that the cut-off point of FIB was 3.34 g/L, the cut-off point of D-dimer was 1.01 mg/L, and the cut-off point of ALP was 154.80 U/L. Taking the cut-off value as the critical value, the patients were divided into high and low FIB group, and high and low FIB group had significant differences in bone metastasis (P<0.05). There were significant differences in cT, lymph node metastasis and bone metastasis between high and low D-dimer groups (P<0.05). There were significant differences in cT, distant metastasis and bone metastasis between the high and low ALP groups (P<0.05). Univariate and multivariate Logistic regression analysis showed that ALP value and Gleason score were significantly associated with bone metastases of PCa.

High ALP and Gleason scores can be used as important indicators for the diagnosis of bone metastasis in PCa, while FIB and D-dimer can not be used as independent factors for the diagnosis of bone metastasis in PCa.