To observe the therapeutic effect of percutaneous tibial nerve stimulation (PTNS) combined with solifenacin on patients with overactive bladder (OAB) complicated with stress urinary incontinence (SUI) after radical prostatectomy, and its influence on serum levels of lysine oxidase -1(LOX-1), transforming growth factor -β1(TGF-β1) and connective tissue growth factor (CTGF).

Clinical data of 53 patients with OAB complicated with SUI after radical prostatectomy in Kunshan Hospital of Traditional Chinese Medicine from March 2018 to March 2022 were retrospectively selected and divided into contrast group (25 cases) and combined PTNS group (28 cases) according to treatment methods. The contrast group was treated with pelvic floor muscle training combined with solifenacin, and the combined PTNS group was treated with PTNS on the basis of the contrast group. Both groups were treated for 3 months. The clinical efficacy, bladder function, and adverse reactions were compared between the two groups.

After 3 months of treatment, the total effective rate of the combined PTNS group was higher than the contrast group (P<0.05). After 1, 3 months of treatment, the level of serum LOX-1, the frequency of 24 h urinary incontinence, the frequency of 24 h urination, the frequency of nocturia showed a trend of gradual decrease in the two groups, the levels of serum TGF- β1, CTGF, maximum urinary flow rate, showed a trend of gradual increase, and the differences were statistically significant (P<0.05). After 1, 3 months of treatment, the level of serum LOX-1, the frequency of 24 h urinary incontinence, 24 h urination, nocturia in the combined PTNS group were lower than those in the contrast group, and the levels of serum TGF- β1, CTGF, maximum urine flow rate were higher than those in the contrast group (P<0.05). During the treatment, the total incidence of adverse reactions in the combined PTNS group compared with the contrast group was no significant difference (P>0.05).

PTNS combined with solifenacin in the treatment of patients with OAB complicated with SUI after radical prostatectomy could effectively improve the cytokine level, bladder function and urinary control, without increasing the occurrence of adverse reactions.