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中华腔镜泌尿外科杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 418 -422. doi: 10.3877/cma.j.issn.1674-3253.2025.04.004

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免疫治疗在局部进展期肾癌围手术期治疗中的应用进展
陈琼, 吴卓龙, 黄吉炜()   
  1. 200127 上海交通大学医学院附属仁济医院泌尿科
  • 收稿日期:2025-04-07 出版日期:2025-08-01
  • 通信作者: 黄吉炜
  • 基金资助:
    国家自然科学基金项目(82102748); 上海市自然科学基金滚动项目(24ZR1492000); 上海市重中之重研究中心建设项目(Class B,2023ZZ02014); 上海市卫生健康委员会面上项目(202340077); 北京市希思科临床肿瘤学研究基金会(Y-Gilead2024-PT-0054)

Application of immunotherapy in the perioperative treatment of locally advanced renal cell carcinoma

Qiong Chen, Zhuolong Wu, Jiwei Huang()   

  1. Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2025-04-07 Published:2025-08-01
  • Corresponding author: Jiwei Huang
引用本文:

陈琼, 吴卓龙, 黄吉炜. 免疫治疗在局部进展期肾癌围手术期治疗中的应用进展[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(04): 418-422.

Qiong Chen, Zhuolong Wu, Jiwei Huang. Application of immunotherapy in the perioperative treatment of locally advanced renal cell carcinoma[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2025, 19(04): 418-422.

局部进展期肾癌(la-RCC)包括TNM分期(2017年版美国癌症联合委员会分期)为T1-2N1M0、T3N0-1M0的患者以及部分较局限且未出现远处转移的T4期肾癌,具有较高的术后复发及转移风险,目前主要治疗方法为手术治疗联合围手术期抗肿瘤药物治疗。然而围手术期的最佳治疗策略目前仍未明确,围手术期治疗策略的优化是改善患者预后的关键。近年来,免疫检查点抑制剂(ICIs)在肾癌新辅助及辅助治疗中的应用取得显著进展。本文将描述局部进展期肾癌的围手术期免疫治疗的进展,包括术前新辅助免疫治疗以及术后辅助免疫治疗的相关研究结果,为国内临床工作者提供参考。

Locally advanced renal cell carcinoma (la-RCC) encompasses patients with TNM staging (AJCC 2017 edition) of T1-2N1M0, T3N0-1M0, and T4 cases with localized disease and without distant metastasis. These patients face a high risk of postoperative recurrence and metastasis. The current primary treatment approach involves surgical resection combined with perioperative therapy. However, the optimal perioperative treatment strategy remains undefined, and refining these strategies is critical to improving patient outcomes. In recent years, immune checkpoint inhibitors (ICIs) have demonstrated significant advancements in the neoadjuvant and adjuvant treatment of renal cell carcinoma. This article reviews recent progress in perioperative immunotherapy for la-RCC, including findings from studies on preoperative neoadjuvant immunotherapy and postoperative adjuvant immunotherapy, to provide insights for clinical practitioners.

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