To explore the influence factors of holmium laser prostate enucleation (HoLEP) in patients with benign prostatic hyperplasia (BPH).

Retrospective analysis was made on the clinical data of 100 patients with benign prostatic hyperplasia who received HoLEP in Danyang People's hospital from June 2018 to June 2021. According to the clinical efficacy, the patients were divided into good efficacy group (83 cases) and poor efficacy group (17 cases). Univariate and multivariate logistic regression were used to analyze the influencing factors of the efficacy of HoLEP in patients with BPH. ROC curve was used to analyze the value of residual urine volume, maximum detrusor pressure, and prostatectomy rate in predicting the poor efficacy of HoLEP in patients with BPH.

Univariate analysis showed that compared with the group with good curative effect, the proportion of patients with poor curative effect was higher in the age of 71 to 80 years, the course of disease ≥5 years, and the preoperative international prostate symptom score (IPSS) score of 8 to 35 points, and the group with poor curative effect had more residual urine volume, lower maximum detrusor pressure, and lower prostatectomy rate (P<0.05). According to ROC analysis, preoperative residual urine volume ≥ 51.740 ml, maximum detrusor pressure ≤99.958 cm H₂O, and prostatectomy rate ≤51.395% were the cutoff values for poor efficacy of HoLEP in BPH patients (P<0.05). Multivariate logistic regression analysis showed that advanced age, course of disease ≥5 years, high preoperative IPSS score, significant preoperative residual urine volume, reduced maximum detrusor pressure, and low prostatectomy rate were risk factors for poor efficacy of HoLEP in BPH patients (P<0.05).

HoLEP for patients with BPH may be affected by the patient's age, course of disease, preoperative IPSS score, prostatectomy rate and other factors. In addition, patients with preoperative residual urine volume ≥51.740 ml, maximum detrusor pressure ≤99.958 cm H₂O have a higher risk of poor postoperative efficacy, which should be paid more attention.