Abstract:
Objective To study relevancy of β2 microglobulin (β2-MG) and cystatin C (Cys-C)in patients with renal calculi in Yunfu area and investigate their clinical value in the diagnosis and treatment of renal calculi.
Methods Two hundred patients with kidney stones treated in our hospital from January 2016 to August 2017 were chosen as the research objects (Study Group), which were divided into group A (Ⅰ, n=45), group B (2, n=70), group C (III, n=36), group D (IV, n=49) based on the classification of renal calculi. Two hurdred cases of healthy subjects were selected as control group. Serum β2-MG, Cys-C and Crtinine (Cr) levels of all study subjects were collected and analyzed.
Results Serum β2-MG, Cys-C and Cr in the study group was significantly higher than that in the control group (P<0.05), and the positive rate of serum β2-MG, Cys-C in patients with different grade of renal calculi was more than 70.0%, significantly higher than Cr (P<0.05). Serum β2-MG, Cys-C, Cr were all positively correlated (P<0.05).
Conclusion Serum β2-MG, Cys-C can be used as important laboratory diagnostic indexes for early renal injury in patients with renal calculi in this area and play important roles in the diagnosis and treatment of renal calculi.
Key words:
Yunfu area,
Renal calculi,
β2 microglobulin,
Cystatin C,
Crtinine
Kunpei Lin, Yongjiang Chen, Zhiding Xu. Changes of β-2 microglobulin and cystatin C levels in patients with renal calculi in Yunfu area[J]. Chinese Journal of Endourology(Electronic Edition), 2018, 12(03): 190-193.