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中华腔镜泌尿外科杂志(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 296 -302. doi: 10.3877/cma.j.issn.1674-3253.2025.03.003

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膀胱癌病理报告中常用免疫组化标记物的解读
曾弘1,()   
  1. 1. 510120 广州,中山大学孙逸仙纪念医院病理科
  • 收稿日期:2024-03-05 出版日期:2025-06-01
  • 通信作者: 曾弘
  • 基金资助:
    国家级继续医学教育项目(2023-04-05-200(国))

Interpretation of commonly used immunohistochemical markers in pathological reports of bladder cancer

Hong Zeng1,()   

  1. 1. Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  • Received:2024-03-05 Published:2025-06-01
  • Corresponding author: Hong Zeng
引用本文:

曾弘. 膀胱癌病理报告中常用免疫组化标记物的解读[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(03): 296-302.

Hong Zeng. Interpretation of commonly used immunohistochemical markers in pathological reports of bladder cancer[J/OL]. Chinese Journal of Endourology(Electronic Edition), 2025, 19(03): 296-302.

免疫组化是膀胱癌诊断分型、靶向及免疫治疗效果预测的重要辅助手段,本文将介绍目前膀胱癌病理报告中常用的免疫组化标记物。未来,随着基于免疫组化的尿路上皮癌分子分型和人工智能技术的应用,免疫组化将进一步推动膀胱癌精准诊疗的发展。

Immunohistochemistry is an important adjunct to the diagnosis, classification, and prediction of the efficacy of targeted therapy and immunotherapy in bladder cancer.This paper presents the commonly used immunohistochemical markers in pathological reports of bladder cancer.In the future, with the application of immunohistochemistry-based molecular subtypes of urothelial carcinoma and artificial intelligence technology,immunohistochemistry will further promote the development of precision diagnosis and treatment of bladder cancer.

图1 尿路上皮癌的尿路上皮谱系免疫组化标记物(×200) 注:a 为HE 染色,b、c、d 分别示免疫组化GATA3(+)、 P40(+)、CK5/6(+)
图2 尿路上皮原位癌免疫组化的常用标记(×200) 注:a 为HE 染色,b、c、d 分别示免疫组化P53(+)、CK20(+)、Ki67(+)
表1 尿路上皮癌HER-2 蛋白表达免疫组化染色判读和评分标准[12]
图3 尿路上皮癌HER-2 免疫组化染色(×200) 注:a、b、c、d 分别示HER-2(0)、HER-2(1+)、HER-2(2+)、HER-2(3+)
表2 程序性细胞死亡配体1(PD-L1)不同克隆号抗体在尿路上皮癌中的判断标准及临床诊断阈值[13]
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