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Chinese Journal of Endourology(Electronic Edition) ›› 2025, Vol. 19 ›› Issue (02): 134-139. doi: 10.3877/cma.j.issn.1674-3253.2025.02.002

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Updates of mRNA vaccine research for prostate cancer

Haowei Qiu1,2, Zhen Xu1, Zexiu Xiao3, Yan Xia3, Gaofeng Zha2, Jun Pang1,()   

  1. 1. Department of Urology,the Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 508107,China
    2. Research Center,the Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 508107,China
    3. Shenzhen MagicRNA Biotech,Guangdong 508107,China
  • Received:2024-11-08 Online:2025-04-01 Published:2025-04-01
  • Contact: Jun Pang

Abstract:

The low infiltration of immune cells,especially T cells,in prostate cancer often leads to its classification as an "immune desert",resulting in poor outcomes with immunotherapy,including immune checkpoint inhibitors.The development of mRNA vaccines has progressed rapidly in recent years.mRNA cancer vaccines have been shown to induce tumor-specific T cells and humoral immune responses that enhance the cytotoxicity against tumor cells.This paper reviews the progress and challenges of mRNA vaccines in prostate cancer,providing references for future research and the development of mRNA therapeutics.

Key words: Prostate cancer, mRNA vaccine, Cancer immunotherapy

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